外泌体在布鲁氏菌感染中的调控机制及其应用价值  

Exosomes regulate Brucella infection:mechanism and application value

作　　者：王晓阁 王琦 佟仁冬 朱小洁 王龙喜 王豪杰 胡云皓 朱良全[1] WANG Xiaoge;WANG Qi;TONG Rendong;ZHU Xiaojie;WANG Longxi;WANG Haojie;HU Yunhao;ZHU Liangquan(China Institute of Veterinary Drug Control,Beijing 100081,China)

机构地区：[1]中国兽医药品监察所,北京100081

出　　处：《微生物学通报》2025年第2期552-560,共9页Microbiology China

基　　金：国家重点研发计划(2022YFD1800703);中国兽医药品监察所第三批公益性专项(GY202403)。

摘　　要：外泌体(exosomes)为细胞间通讯的媒介,在布鲁氏菌(Brucella)的传播和免疫调节中发挥重要作用。本文重点阐明了外泌体在布鲁氏菌感染中的调控作用,探讨了外泌体在诊断、疫苗及药物中的应用价值,以期为利用外泌体防控布鲁氏菌等胞内菌提供参考。Exosomes are the mediators of intercellular communication and play a key role in the spread and immune regulation of Brucella.This article elaborates on the regulatory role of exosomes in Brucella infection and discusses the application value of exosomes in diagnosis,vaccines,and drugs,aiming to provide reference for the application of exosomes in the prevention and control of intracellular bacteria such as Brucella.

关 键 词：布鲁氏菌 外泌体 免疫调节 防控 

分 类 号：R516.7[医药卫生—内科学]