GNB2蛋白的研究进展  

Research progress of GNB2 protein

作　　者：熊黎 阳丽红 范雨鑫 邓欢 向尹(综述) 杨阳(审校)[1] XIONG Li;YANG Lihong;FAN Yuxin;DENG Huan;XIANG Yin;YANG Yang(Department of Clinical Laboratory,Leshan People′s Hospital,Leshan,Sichuan 614000,China;North Sichuan Medical College,Nanchong,Sichuan 637000,China)

机构地区：[1]乐山市人民医院检验科,四川乐山614000 [2]川北医学院,四川南充637000

出　　处：《国际检验医学杂志》2025年第5期616-619,共4页International Journal of Laboratory Medicine

基　　金：乐山市重点研究项目(23SZD019)。

摘　　要：鸟苷酸结合蛋白亚基β-2(GNB2)是G蛋白家族的重要组成部分,在细胞信号传导过程中GNB2在G蛋白复合物中起到结构支撑和调控作用,确保信号的正确传递和放大,与受体相互作用并调节各种效应器酶和离子通道,介导多种生理功能。因此GNB2在细胞信号传导过程中扮演着关键的角色,参与调控细胞的增殖、分化和迁移等生物过程。该文综述了GNB2的研究进展,着重探讨其结构、功能、调控机制、疾病相关性及在肿瘤研究中的重要性。Guanylate binding protein subunitβ-2(GNB2)is an important part of G protein family.In the process of cell signal transduction,GNB2 plays a structural support and regulatory role in G protein complex,ensuring the correct transmission and amplification of signals,interacting with receptors and regulating various effector enzymes and ion channels,and mediating a variety of physiological functions.Therefore,GNB2 plays a key role in cell signaling,and participates in the regulation of cell proliferation,differentiation and migration and other biological processes.This article reviews the research progress of GNB2,focusing on its structure,function,regulatory mechanism,disease correlation and importance in tumor research.

关 键 词：鸟苷酸结合蛋白亚基β-2 细胞信号传导 调控机制 

分 类 号：R446.1[医药卫生—诊断学]