结肠癌术后感染sTREM-1与铜蓝蛋白和红细胞分布宽度及其诊断价值  

sTREM-1 with ceruloplasmin and erythrocyte distribution width in patients with postoperative infection of colon cancer and its diagnostic value

作　　者：方莉亚 朱炜 卜亚美 孙红 潘云燕 FANG Liya;ZHU Wei;BU Yamei;SUN Hong;PAN Yunyan(First Affiliated Hospital of Huzhou Normal University,Huzhou,Zhejiang 313000,China)

机构地区：[1]湖州师范学院附属第一医院胃肠外科,浙江湖州313000

出　　处：《中华医院感染学杂志》2025年第3期379-383,共5页Chinese Journal of Nosocomiology

基　　金：浙江省医药卫生科技计划基金资助项目(2022ZH055)。

摘　　要：目的探讨结肠癌术后感染可溶性髓系细胞表达的触发受体-1(sTREM-1)与铜蓝蛋白(CER)和红细胞分布宽度(RDW)及其诊断价值,为疾病早期诊断提供参考。方法选取2019年10月—2022年1月湖州师范学院附属第一医院73例结肠癌术后感染患者设为研究组,根据1:1配比原则,另选取同期术后无感染患者73例设为对照组,测定sTREM-1、CER、RDW水平。比较两组sTREM-1、CER、RDW水平及急性生理与慢性健康状况Ⅱ(APACHEⅡ)评分,通过logistic多因素回归模型分析sTREM-1、CER、RDW与结肠癌术后感染的关联性,采用Pearson分析各指标水平与APACHEⅡ评分的相关性,采用受试者工作特征(ROC)曲线分析各指标诊断结肠癌术后感染的诊断效能;分析感染控制者与未控制者以上指标水平。结果研究组sTREM-1、CER、RDW水平、APACHEⅡ评分分别为(58.56±10.31)pg/ml、(464.80±61.44)mg/L、(16.38±2.30)%、(21.26±3.69)分均高于对照组(P<0.05);sTREM-1、CER、RDW水平与APACHEⅡ评分呈正相关(r=0.705、0.690、0.687,P均<0.05);结肠癌术后感染与sTREM-1、CER、RDW显著相关(P<0.05);CER诊断结肠癌术后感染的曲线下面积为0.813,大于sTREM-1、RDW,其最佳诊断敏感度为86.30%,特异度为65.75%;感染控制者治疗前sTREM-1、CER、RDW分别为(38.81±10.30)pg/ml、(313.56±56.10)mg/L、(11.93±2.10)%均低于感染未控制者(P<0.05)。结论结肠癌术后感染患者sTREM-1、C ER及RDW表达异常升高,与感染发生关系密切,且与患者病情程度呈正相关,在结肠癌术后感染诊断上具有一定的价值。OBJECTIVE To investigate serum soluble triggering receptor expressed on myeloid cells-1(sTREM-1)with to ceruloplasmin(CER)and red blood cell distribution width(RDW)in patients with postoperative colon cancer infection and its diagnostic value,and to provide references for early diagnosis of the disease.METHODS Seventy-three patients with postoperative colon cancer infections in First Affiliated Hospital of Huzhou Normal University from Oct.2019 to Jan.2022 were selected as the study group,and 73 patients without postoperative infections during the same period were selected as the control group according to the principle of 1:1 ratio,and sTREM-1,CER,and RDW levels were measured.The sTREM-1,CER,RDW levels and acute physiological and chronic health status scale II(APACHEII)scores were compared between the two groups,multivariate logistic regression analysis model was used to analyze the correlation between sTREM-1,CER,RDW levels and infections after colon cancer,Pearson analysis was used to analyze the correlation between each index level and APACHEII score,and the receiver operating characteristic(ROC)curve was used to explore the diagnostic efficacy of each indicator for postoperative infection in colon cancer The level of the above indicators in the infection-controlled patients versus the infection-uncontrolled patients were analyzed.RESULTS The levels of sTREM-1,CER,RDW,and APACHE II score in the study group were(58.56±10.31)pg/ml,(464.80±61.44)mg/L,(16.38±2.30)%,and(21.26±3.69)points,respectively,which were higher than those in the control group(P<0.05).The levels of sTREM-1,CER,and RDW were positively correlated with the APACHE II score(r=0.705,0.690,0.687,all P<0.05).The postoperative infection of colon cancer was significantly correlated with sTREM-1,CER,and RDW(P<0.05).The area under the curve of CER for diagnosing postoperative infection in colon cancer patients was 0.813,which was higner than that of sTREM-1 and RDW,with the optimal diagnostic sensitivity of 86.30%,and the specificity of 65.75%.The p

关 键 词：结肠癌 术后感染 可溶性髓系细胞表达的触发受体-1 铜蓝蛋白 红细胞分布宽度 诊断价值 

分 类 号：R619.3[医药卫生—外科学]