新生儿肺炎25(OH)D3、LTB4、MCP-1、MMP-9、SAA水平及其对病情程度的预测价值  

25(OH)D3,LTB4,MCP-1,MMP-9 and SAA levels in newborns with neonatal pneumonia and their predictive value for the severity of the disease

作　　者：刘延霞 林则彬 林健英 徐莉 LIU Yanxia;LIN Zebin;LIN Jianying;XU Li(Hainan Modern Women and Children's Hospital,Haikou,Hainan 570000,China;不详)

机构地区：[1]海南现代妇女儿童医院新生儿科,海南海口570000 [2]海南医学院第二附属医院儿科,海南海口570216

出　　处：《中华医院感染学杂志》2025年第3期416-420,共5页Chinese Journal of Nosocomiology

基　　金：海南省卫生健康行业科研基金资助项目(22A200267)。

摘　　要：目的探讨新生儿肺炎血清25羟维生素D3[25(OH)D3]、白三烯B4(LTB4)、单核细胞趋化因子蛋白1(MCP-1)、基质金属蛋白酶9(MMP-9)、淀粉样蛋白A(SAA)及其对病情程度的预测价值。方法选取海南现代妇女儿童医院2020年11月—2023年11月收治的新生儿肺炎患儿81例纳入研究(研究组),根据病情程度分为重症组(36例)和轻症组(45例),根据感染类型分为细菌性感染组(47例)和非细菌性感染组(34例)。另选同期健康体检新生儿83名为对照组。比较各组25(OH)D3、LTB4、MCP-1、MMP-9、SAA表达水平;采用受试者工作特征(ROC)曲线分析25(OH)D3、LTB4、MC P-1、MMP-9、SAA对新生儿肺炎的诊断价值。结果研究组LTB4、MCP-1、MMP-9、SAA水平分别为(133.47±44.38)pg/ml、(70.14±23.35)ng/ml(179.86±59.86)ng/ml、(19.75±6.52)μg/L高于对照组(P<0.05),重症组高于轻症组(P<0.05),细菌性感染组高于非细菌性感染组(P<0.05)。研究组25(OH)D3为(14.56±4.32)μg/L低于对照组(P<0.05),重症组低于轻症组(P<0.05),细菌性感染组低于非细菌性感染组(P<0.05)。绘制ROC曲线获得联合检测对新生儿肺炎诊断的曲线下面积(AUC)相较各项单独检测更高(P<0.05)。结论新生儿肺炎发生后LTB4、MCP-1、MMP-9、SAA呈高表达,25(OH)D3呈低表达,且与患儿病情程度和感染类型密切相关,5个指标联合检测有助于诊断新生儿肺炎。OBJECTIVE To investigate serum 25-hydroxy vitamin D3(25(OH)D3),leukotriene B4(LTB4),monocyte chemokine protein 1(MCP-1),matrix metalloproteinase 9(MMP-9)and amyloid protein A(SAA)levels in newborns with neonatal pneumonia and their predictive value for the severity of the disease.METHODS Eighty-one newborns with neonatal pneumonia admitted to Hainan Modern Women and Children's Hospital from Nov.2020 to Nov.2023 were selected as the study group and divided into the severe(36 cases)and the mild groups(45 cases)according to the severity of the disease,and were divided into the bacterial infection(47 cases)and the nonbacterial infection groups(34 cases)according to the type of infection.Another 83 neonates with healthy physical examination during the same period were selected as the control group.The expression of serum 25(OH)D3,LTB4,MCP-1,MMP-9 and SAA levels in each group were compared.Receiver operating characteristic curve(ROC)was used to analyze the diagnostic values of 25(OH)D3,LTB4,MCP-1,MMP-9 and SAA for neonatal pneumonia.RESULTS The levels of LTB4,MCP-1,MMP-9 and SAA in the study group were(133.47±44.38)pg/ml,(70.14±23.35)ng/ml,(179.86±59.86)ng/ml and(19.75±6.52)μg/L respectively,higher than those in the control group(P<0.05),which in the severe group were higher than those in the mild group(P<0.05),and in the bacterial infection group were higher than those in the non-bacterial infection group(P<0.05).The 25(OH)D3 in the study group was(14.56±4.32)μg/L lower than that in the control group(P<0.05),which in the severe group was lower than that in the mild group(P<o.05),and in the bacterial infection group was lower than that in the non-bacterial infection group(P<o.05).The area under the curve(AUC)of the combined detection for the diagnosis of neonatal pneumonia by plotting ROC curve was higher than that of each single index(P<0.05).CONCLUSIONS After the occurrence of neonatal pneumonia,serum LTB4,MCP-1,MMP-9 and SAA are highly expressed,and 25(OH)D3 is lowly expressed,which is closely related to the

关 键 词：新生儿肺炎 25羟维生素D3 白三烯B4 单核细胞趋化因子蛋白1 基质金属蛋白酶9 淀粉样蛋白A 受试者工作特征曲线 预测价值 

分 类 号：R722.135[医药卫生—儿科]