IL-9和Th9细胞在过敏性哮喘中的作用机制及研究现状  

Current status of research in the field of IL-9 and Th9 cells in allergic asthma

作　　者：尚腾泽 李俊达 徐迎阳 关凯 SHANG Tengze;LI Junda;XU Yingyang;GUAN Kai(Department of Allergy,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment on Allergic Diseases,National Clinical Research Center for Dermatologic and Immunologic Diseases,Beijing 100730,China)

机构地区：[1]中国医学科学院,北京协和医学院,北京协和医院变态(过敏)反应科,过敏性疾病精准诊疗研究北京市重点实验室,国家皮肤与免疫疾病临床医学研究中心,北京100730

出　　处：《中华临床免疫和变态反应杂志》2024年第6期513-518,共6页Chinese Journal of Allergy & Clinical Immunology

基　　金：国家自然科学基金项目(82070033);中国医学科学院医学与健康科技创新工程项目(2021-I2M-1-017);国家自然科学基金面上项目(82370041)。

摘　　要：过敏性哮喘是一种由变应原诱发的以气道高反应性、慢性炎症为特征的疾病。多种细胞及细胞因子在过敏性哮喘的发生、发展中发挥重要作用,如Th2细胞、肥大细胞、嗜碱性粒细胞、嗜酸性粒细胞,以及IL-4、IL-5、IL-13等。近年来研究发现,IL-9和Th9细胞在过敏性疾病的发生中也发挥重要作用,IL-9通过激活肥大细胞、固有淋巴细胞、T淋巴细胞、巨噬细胞等多种细胞,促进过敏性哮喘的发生发展。本文针对IL-9和Th9细胞在过敏性哮喘中的作用机制和研究现状进行综述。Allergic asthma is one kind of diseases characterized by airway hyperresponsiveness and chronic inflammation which induced by allergens.Various cells and cytokines play important roles in development and progression of allergic asthma,such as Th2 cells,mast cells,basophils,eosinophils,IL-4,IL-5,IL-13,etc.In recent years,it has been found that Th9 cells and IL-9 also play significant roles in allergic diseases.IL-9 can promote development of allergic asthma by acting on various cells,including mast cells,lymphocytes and macrophages.The mechanisms and current status of research in the field of roles of IL-9 and Th9 in allergic asthma were reviewed in this article.

关 键 词：过敏性哮喘 IL-9 TH9 

分 类 号：R56[医药卫生—呼吸系统]