罗伊氏乳杆菌降胆固醇的作用与机制研究进展  

Progress in studies on the action and mechanism of Lactobacillus reuteri in lowering cholesterol

作　　者：安昊杰 高江梅 钟秀玲 颜青 龙程[2] 饶军华 AN Haojie;GAO Jiangmei;ZHONG Xiuling;YAN Qing;LONG Cheng;RAO Junhua(Guangdong Key Laboratory of Animal Conservation and Resource Utilization,Guangdong Public Laboratory of Wild Animal Conservation and Utilization,Institute of Zoology,Guangdong Academy of Sciences,Guangzhou 510260,China;School of Life Science,South China Normal University,Guangzhou 510631,China;Zhuzhou Central Hospital,Zhuzhou 412007,China)

机构地区：[1]广东省科学院动物研究所,广东省动物保护与资源利用重点实验室,广东省野生动物保护与利用公共实验室,广州510260 [2]华南师范大学生命科学学院,广州510631 [3]株洲市中心医院,湖南株洲412007

出　　处：《中国实验动物学报》2025年第1期108-116,共9页Acta Laboratorium Animalis Scientia Sinica

基　　金：国家自然科学基金(82200966);广东省科学院科技发展专项(2022GDASZH-2022010110)。

摘　　要：由高胆固醇血症引起的动脉粥样硬化心血管疾病已成为影响人类生命健康的主要威胁之一。近年来,具有降胆固醇作用的益生菌已成为研究热点。研究表明,罗伊氏乳杆菌能够通过调节宿主肝与肠上皮细胞固醇调节元件结合蛋白2、3-羟基-3-甲基戊二酰辅酶A还原酶、胆固醇7α羟化酶等的基因表达,减少内源胆固醇合成、调节胆固醇转运和促进胆固醇分解,从而降低宿主血清中总胆固醇和低密度脂蛋白胆固醇的水平。本文对已报道的罗伊氏乳杆菌降胆固醇作用与机制的研究进行综述,旨在为高胆固醇血症的治疗及降胆固醇益生菌的研发提供参考。Cardiovascular diseases that develop from hypercholesterolemia-induced atherosclerosis have emerged as a significant threat to human health.Recently,probiotics exhibiting cholesterol-lowering properties have emerged as a prominent area of research.Numerous studies have demonstrated that Lactobacillus reuteri can effectively reduce endogenous cholesterol synthesis,regulate cholesterol transport,and promote cholesterol degradation by glutaryl coenzyme A reductase,and cholesterol 7 alpha-hydroxylase,in both the liver and intestinal epithelial cells of the host.This leads to a notable decrease in total cholesterol and low-density lipoprotein cholesterol levels in the host serum.The present paper offers a comprehensive overview of the underlying mechanisms responsible for the cholesterol-lowering effects exerted by L.reuteri,aiming to provide valuable insights into the treatment of hypercholesterolemia and the development of probiotics with cholesterol-lowering properties.

关 键 词：益生菌 罗伊氏乳杆菌 降胆固醇 作用与机制 

分 类 号：Q95-33[生物学—动物学]