肌少症小鼠模型运动功能测评方法的研究进展  

Research progress of motor function evaluation methods in animal models of sarcopenia

作　　者：杨森 张勇[2] 周志雄[3] 曾平 YANG Sen;ZHANG Yong;ZHOU Zhixiong;ZENG Ping(Institute of Physical Education and Training,Capital University of Physical Education and Sports,Beijing 100191,China;Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences,School of Basic Medicine,Peking Union Medical College,Beijing 100005,China;Institute of Artificial Intelligence in Sports,Capital University of Physical Education and Sports,Beijing 100191,China;Health and Medical Department,Peking Union Medical College Hospital,Chinese Academy of Medical Science,Beijing 100730,China)

机构地区：[1]首都体育学院体育教育训练学院,北京100191 [2]中国医学科学院基础医学研究所北京协和医学院基础学院,北京100005 [3]首都体育学院体育人工智能研究院,北京100191 [4]中国医学科学院北京协和医院保健医疗部,北京100730

出　　处：《中国实验动物学报》2025年第1期117-126,共10页Acta Laboratorium Animalis Scientia Sinica

基　　金：中央高水平医院临床科研专项(2022-PUMCH-B-133);国家重点研发项目资助(2022YFA0806002)。

摘　　要：肌少症是一种与年龄相关的肌肉退行性疾病。自然衰老小鼠是研究肌少症的常用动物模型。由于肌少症的核心病理特征是骨骼肌质量和肌肉力量的显著减少,运动行为实验是其主要的评价方式。目前,肌少症小鼠运动功能检测方法基于肌肉耐力、力量、平衡和协调能力为主要特征进行设计,常用方法包括跑台力竭、自愿转轮、抓力、倒置网格、转棒和平衡木等测试。通过整理国内外关于肌少症小鼠运动功能测评方法,对其检测原理、测试程序、优缺点、评价指标和适用疾病模型等进行系统总结,提出可操作的测评方案,有助于研究者根据研究目的选择适当的测评方法。同时也对运动功能测评技术的创新特征进行归纳,有助于运动功能测评技术的不断更新,对肌少症的深入研究具有指导意义。Sarcopenia is an age-related skeletal muscle degenerative disease.Physiologically aging mice are the most commonly used animal model for studying sarcopenia.As sarcopenia is characterized by decreased skeletal muscle mass and reduced muscle strength,exercise performance as a reflection of muscle function is widely used to evaluate sarcopenia.Methods of evaluating the motor function of sarcopenia mouse models are generally designed based on muscle endurance,muscle strength,coordination,and balance.The method include tests such as treadmill exhaustion,voluntary wheel use,grip strength,horse grid,bars and balance beam tests.By collating recent publications,we have systematically summarized the method used for evaluating motor function,including the tests’principles,procedures,evaluation indexes,advantages,and disadvantages.We then propose an operational program for evaluating the sarcopenia phenotype,which will be of help to researchers wishing to choose evaluation method appropriate to their specific research purposes.Further innovative technology for assessing motor function that could be instructive in the evaluation of skeletal muscle function and diagnosis of sarcopenia is summarized.

关 键 词：肌少症 小鼠 运动功能测评 

分 类 号：Q95-33[生物学—动物学]