模式生物斑马鱼在放射医学研究中的应用现状  

Application status of the model organism zebrafish in radiation medicine research

作　　者：董娟聪[1] 王婧洁[1] 于金环 程娇 党旭红[1] 杨国栋 DONG Juancong;WANG Jingjie;YU Jinhuan;CHENG Jiao;DANG Xuhong;YANG Guodong(China Institute for Radiation Protection,Taiyuan 030006,China;China-Korea(Changchun)International Cooperation Demonstration Zone Center for Disease Control and Prevention,Changchun 130051,China;the 404 Company Limited,China National Nuclear Corporation,Jiayuguan 735100,China)

机构地区：[1]中国辐射防护研究院,太原030006 [2]中韩(长春)国际合作示范区疾病预防控制中心,长春130051 [3]中核四0四有限公司,甘肃嘉峪关735100

出　　处：《中国实验动物学报》2025年第1期141-148,共8页Acta Laboratorium Animalis Scientia Sinica

基　　金：山西省基础研究计划青年科学研究项目(202103021223454)。

摘　　要：斑马鱼作为一种介于细胞与传统哺乳动物之间的模式生物,凭借其独特的优势在放射医学研究中展现出广阔的应用前景。其与人类基因有87%的同源性、高繁殖力、胚胎期短、透明易观察的胚胎等特点,使其成为放射医学研究的重要工具。近期,斑马鱼在低剂量辐射生物效应、放射治疗及辐射损伤防治等放射医学关键领域的应用取得了显著进展。本文综述了这些应用状况,旨在挖掘斑马鱼在放射医学研究中的潜在价值,为相关领域的实验研究提供借鉴与参考。As a model organism that bridges the gap between cells and traditional mammals,the zebrafish has broad application prospects in radiation medicine research.Among its unique advantages are its characteristics of a high homology with human genes,high fertility,short embryonic period,and transparent and easy to observe embryos,making it an important tool in radiation medicine research.Recently,remarkable progress has been made in the application of zebrafish to investigate low-dose radiation biological effects,radiation therapy,and radiation damage prevention and treatment,key areas of radiation medicine.In this paper,these applications are reviewed;we explore the value of zebrafish in radiation medicine research and provide a reference for experimental research in related fields.

关 键 词：斑马鱼 胚胎 放射医学 

分 类 号：Q95-33[生物学—动物学]