参附注射液对脓毒症相关急性肾损伤的影响  

Effect of Shenfu injection on sepsis‑associated acute kidney injury

作　　者：张月银 刘兴[2] 杨亚东 ZHANG Yueyin;LIU Xing;YANG Yadong(Yangtze University Medical Science Center,Jingzhou 434023,Hubei,China;Dept.of Critical Care Medicine,Huanggang Central Hospital Affiliated to Yangtze University,Huanggang 438000,Hubei,China)

机构地区：[1]长江大学医学部,湖北荆州434023 [2]长江大学附属黄冈市中心医院重症医学科,湖北黄冈438000

出　　处：《武汉大学学报(医学版)》2025年第2期252-257,共6页Medical Journal of Wuhan University

基　　金：中华国际医学交流基金会资助项目(编号:Z‑2017‑24‑2028‑29)。

摘　　要：目的:研究参附注射液(SF)对脓毒症相关急性肾损伤的疗效,并探讨其机制。方法:采用前瞻性研究,选取长江大学附属黄冈市中心医院重症医学科收治的符合条件的患者,SF组和对照组各16例。对照组采用常规西医治疗方法,SF组在常规西医治疗的方法上加用SF(100 mL,ivd,qd),疗程7 d。记录两组治疗前及治疗后7 d的SOFA评分、血乳酸(Lac)和平均动脉压(MAP),炎症指标包括白细胞介素‑6(IL‑6)和降钙素原(PCT),肾功能指标血清肌酐(Scr)、尿素氮(BUN)和每小时尿量(Uo/h),凝血功能指标血小板(PLT)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)和D‑二聚体,并记录总住院天数、入住ICU天数、7 d病死率及28 d病死率。结果:SF组患者的SOFA评分、Lac、IL‑6、PCT、Scr、PT和D‑二聚体在第7天低于同期对照组(P<0.05)。SF组患者的Uo/h在第7天高于同期对照组(P<0.05),SF组患者入组12 h MAP和入组24 h MAP高于同期对照组(P<0.05)。SF组BUN、PLT和APTT在第7天与同期对照组差异无统计学意义(P>0.05)。两组的总住院天数、入住ICU天数、7 d病死率及28 d病死率差异无统计学意义(P>0.05)。结论:SF对脓毒症相关急性肾损伤患者的肾功能有一定的改善作用,同时可以改善患者的炎症指标,降低乳酸水平。Objective:To study the therapeutic effect of Shenfu injection(SF)on sepsis‑associated acute kidney injury(AKI)and explore its mechanism.Methods:A prospective study was conducted.Eligible patients admitted to the Department of Critical Care Medicine of Huanggang Central Hospital Affiliated to Yangtze University were selected.There were 16 cases in SF group and 16 cases in the control group.The control group received conventional treatment,and SF group was treated with SF(100 mL,ivd,qd)for 7 days based on conventional treatment.The SOFA score,blood lactic acid(Lac)and mean arterial pressure(MAP),inflammatory indicators including interleukin‑6(IL‑6)and procalcitonin(PCT),renal function indicators including serum creatinine(Scr),blood urea nitrogen(BUN)and urine volume per hour(Uo/h)were recorded before and 7 days after treatment.Platelet(PLT),prothrombin time(PT),activated partial thromboplastin time(APTT)and D‑dimer were measured.The total length of hospital stay,ICU stay,7‑day mortality and 28‑day mortality were recorded.Results:The SOFA score,Lac,IL‑6,PCT,Scr,PT and D‑dimer of SF group were lower than those of the control group on the seventh day(P<0.05).The Uo/h of SF group patients was higher than that of the control group on the seventh day(P<0.05).The MAP at 12 hours and 24 hours in SF group were higher than those in the control group(P<0.05).There was no significant difference in BUN,PLT and APTT between SF group and the control group on the seventh day(P>0.05),as well as no significant differences were found in the length of hospital stay,ICU stay,7‑day mortality and 28‑day mortality(P>0.05).Conclusion:SF can improve the renal function of patients with sepsis‑associated acute kidney injury to a certain extent,improve inflammatory indicators and reduce the level of lactic acid.

关 键 词：参附注射液 脓毒症相关急性肾损伤 肾功能 

分 类 号：R45[医药卫生—治疗学]