过氧化氢空气消毒不良反应调查研究  

Investigation on adverse reactions of hydrogen peroxide air disinfection

作　　者：刘新庆 刘皓 LIU Xin-qing;LIU Hao(Fushun Municipal Centers for Disease Control and Prevention,Fushun 113014,China;The Northern Theater Command General Hospital)

机构地区：[1]抚顺市疾病预防控制中心,辽宁抚顺113014 [2]北部战区总医院

出　　处：《中国消毒学杂志》2025年第2期105-107,共3页Chinese Journal of Disinfection

摘　　要：目的 调查过氧化氢空气消毒的不良反应情况及影响因素,以便为科学消毒提供依据。方法 通过问卷调查的方式了解暴露于过氧化氢空气消毒时/后环境的人群不良反应情况,分析相关影响因素及原因并提供解决方案。结果 暴露于过氧化氢空气消毒环境的238人次中,呼吸道刺激反应43人次,占18.1%;眼结膜刺激反应38人次,占16.0%;皮肤刺激反应13人次,占5.5%。单因素分析显示,性别、接触次数、口罩类型、接触时机和接触浓度的不良反应差异有统计学意义(P<0.05)。接触次数、停留时间和口罩类型对呼吸道刺激反应差异有统计学意义(P<0.05),接触时机对眼结膜刺激反应差异有统计学意义(P<0.05),接触次数和接触时机对皮肤刺激反应差异有统计学意义(P<0.05)。多因素分析显示接触次数、口罩类型和接触浓度3个因素可能为不良反应的独立影响因素。结论 消毒过程中需佩戴适宜的呼吸防护装备,合理降低消毒剂浓度、缩短消毒作业时长,尽量减少人员对消毒剂的意外暴露。Objective To investigate and analyze the adverse reactions and influencing factors of air disinfection with hydrogen peroxide disinfectant,and to provide improvement measures,so as to provide basis for scientific disinfection.Methods A questionnaire survey was conducted to understand the adverse reactions of people exposed to hydrogen peroxide air disinfection during/after the environment,and relevant influencing factors and causes were analyzed and solutions were provided.Results Among 238 individuals exposed to an environment disinfected with hydrogen peroxide,43(18.1%)experienced respiratory irritation.Additionally,there were 38(16.0%)cases of ocular conjunctival irritation,and skin irritation was noted in 13(5.5%)patients.Univariate analysis revealed statistically significant differences in adverse reactions based on gender,exposure duration,mask type,timing of exposure,and concentration levels(P<0.05).Contact frequency,duration of stay,and mask type significantly influenced the respiratory irritation response(P<0.05),while timing of contact had a notable impact on conjunctival irritation response(P<0.05).Furthermore,both contact frequency and timing were statistically significant concerning skin irritation responses(P<0.05).Multi-factorial analysis indicated that exposure frequency,mask type,and concentration might serve as independent factors contributing to adverse reactions.Conclusion It is imperative to utilize appropriate respiratory protective equipment during disinfection processes.Concentrations may be judiciously reduced while working durations are minimized to mitigate accidental exposure.

关 键 词：过氧化氢 空气消毒 不良反应 

分 类 号：R187[医药卫生—流行病学]