生物熵在药物研究中的应用  

Application of Bio-entropy in Drug Evaluation

作　　者：郭慧慧 高天乐 马晓蕾 铁偲 蒋建东 GUO Huihui;GAO Tianle;MA Xiaolei;TIE Cai;JIANG Jiandong(Institute of Materia Medica,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100050,China;School of Chemical and Environmental Engineering,China University of Mining and Technology,Beijing,100083,China;Institute of Medicinal Biotechnology,Chinese Academy of Medical Science,Peking Union Medical College,Beijing 100050,China)

机构地区：[1]中国医学科学院北京协和医学院药物研究所,天然药物活性物质与功能国家重点实验室,北京100050 [2]中国矿业大学(北京)化学与环境工程学院,北京100083 [3]中国医学科学院北京协和医学院医药生物技术研究所,北京100050

出　　处：《中国药学杂志》2025年第3期209-213,共5页Chinese Pharmaceutical Journal

基　　金：国家自然科学基金项目资助(82104254,82374061);中国工程院战略研究与咨询项目资助(2023-XZ-88)。

摘　　要：熵是一个源于物理学的概念,表示物质紊乱的程度。熵增定律是揭示事物消亡的自然规律。在生物学领域,也可用熵来度量生命活动过程中的质量,一般来说,生物熵越低越好。生命体依赖其自组织、防御、自愈、抗磨损和适应等负熵能力来对抗熵增,从而逆转疾病抵抗衰老,保持健康。而药物治疗的实质是作为外部干预的力量,通过增强以上某种或几种能力,产生负熵效应,协助机体恢复至有序状态。笔者探讨了生物熵在药物研究中的应用,期望未来能够利用生物熵更正确地认识药物靶点、解释药物作用机制、设计新药以及科学地评估药物(包括中药)的疗效及安全性。The concept of entropy is originated from physics which represents a degree of disorder.Entropy increase is a natural law for extinction of things.In the field of life science,entropy could be used to measure the quality of life.Organisms utilize their inherent negative entropy mechanisms of self-organization,defense,self-healing,wear resistance,and adaptability to counteract entropy increase,and thus to cure various diseases and curb aging processes,while maintaining optimal health.As an external intervention,good drugs could trigger negative entropy mechanisms by enhancing one or more of the above machineries,thus assist the body to recover.This article explores the potential applications of biological entropy in drug discovery research,aiming to leverage its power in the future for a good understanding of drug targets,elucidation of drug mechanisms,rational design of novel drugs and rigorous evaluation of drug efficacy,especially pertinent to multi-target drugs.

关 键 词：生物熵 高度有序 生理信号熵 中药 药效评价 

分 类 号：R966[医药卫生—药理学]