儿童肺炎支原体感染Ficolin-3、STAT3、TLR4、NF-κB水平及其诊断价值  

Levels of Ficolin-3,STAT3,TLR4 and NF-κB in children with Mycoplasma pneumoniae infection and their diagnostic values

作　　者：谢家平 李小梅[1] 谭凤华 谭美丹 XIE Jiaping;LI Xiaomei;TAN Fenghua;TAN Meidan(Chenzhou First People's Hospital,Chenzhou,Hunan 423000,China)

机构地区：[1]郴州市第一人民医院儿童感染科,湖南郴州423000 [2]郴州市第一人民医院转化医学研究中心,湖南郴州423000

出　　处：《中华医院感染学杂志》2025年第4期582-586,共5页Chinese Journal of Nosocomiology

基　　金：湖南创新型省份建设专项任务计划基金资助项目(2021ZK4382)。

摘　　要：目的 探讨儿童肺炎支原体感染的临床特征,并分析血浆纤维凝胶蛋白-3(Ficolin-3)、外周血信号传导与转录激活因子3(STAT3)、Toll样受体4(TLR4)、核因子-κB(N F-κB)对其诊断价值。方法 选择2022年1月-2023年12月郴州市第一人民医院收治的168例肺炎支原体感染患儿作为研究组,根据病情程度将其分为重症组(n=59)和轻症组(n=109),另外选择同期于郴州市第一人民医院进行体检的健康儿童170名作为健康组。比较各组临床特征,比较各组Ficolin-3、STAT3、TLR4、NF-κB水平。采用受试者工作特征(ROC)曲线分析Ficolin-3、STAT3、TLR4、NF-κB对儿童肺炎支原体感染的诊断价值。结果 重症组发热比例高于轻症组(P <0.001),住院天数长于轻症组(P<0.001)。研究组Ficolin-3、STAT3、TLR4、NF-κB水平分别为(33.89±9.12)μg/L、(2.47±0.82)、(2.20±0.73)、(2.54±0.80),高于健康组(P<0.05)。重症组Ficolin-3及STAT3、TLR4、NF-κB水平高于轻症组(P<0.05);将研究组纳入阳性,健康组纳入阴性进行ROC分析,结果显示,血浆Ficolin-3、外周血STAT3、TLR4、NF-κB联合检测诊断儿童肺炎支原体感染的曲线下面积(AUC)为0.927,高于各指标单一检测(P<0.05)。结论 重症肺炎支原体感染患儿的临床特征主要表现为发热,且住院时间较长,血浆Ficolin-3、外周血STAT3、TLR4、NF-κB在肺炎支原体感染患儿中呈高表达,四者可参与患儿病情进展过程,且四者联合检测对肺炎支原体感染患儿的诊断价值更高。OBJECTIVE To investigate the clinical features of Mycoplasma pneumoniae infection in children and an-alyze the diagnostic values of plasma fibrogelatin-3(Ficolin-3),peripheral blood signal transducer and activator of transcription 3(STAT3),Toll-like receptor 4(TLR4)andnuclearfactor-εB(NF-κB).METHODS Totally 168 children infected with Mycoplasma pneumoniae admitted to the First People's Hospital of Chenzhou from Jan.2022 to Dec.2023 were selected as the study group and divided into the severe(n=59)and mild group(n=109)on the basis of the severity of disease,another 170 healthy children who underwent physical examination during the same period were as the healthy group.The clinical characteristics and the levels of Ficolin-3,STAT3,TLR4 and NF-kB in each group were compared.The diagnostic values of Ficolin-3,STAT3,TLR4 and NF-kB were ana-lyzed by the receiver operating characteristics(ROC)curve.RESULTS The proportion of patients in the fever range in the severe group was higher than that in the mild group(P<0.001),and hospital stay was longer than that in the mild group(P<0.001).The levels of Ficolin-3,STAT3,TLR4 and NF-κB in the study group were(33.89±9.12)μg/L,(2.47±0.82),(2.20±0.73)and(2.54±0.80),respectively,whichwerehigher than those in the healthy group(P<0.05).The levels of above indicators in the severe group were higher than those in the mild group(P<0.05).The area under the curve(AUC)of the combined detection of Ficolin-3,STAT3,TLR4 and NF-κB was 0.927,which was higher than that of single indicator(P<0.05).CONCLUSION Children with severe Mycoplasma pneumoniae infection are mainly manifested as fever and longer hospital stay.Plasma Fi-colin-3,STAT3,TLR4 and NF-κB in peripheral blood are highly expressed and participate in the progression of disease,and combined detection of the four indicators possesses high diagnostic value for Mycoplasma pneumoni-ae infection in children.

关 键 词：儿童 肺炎支原体感染 纤维凝胶蛋白-3 信号传导与转录激活因子3 Toll样受体4 核因子-ΚB 诊断价值 

分 类 号：R563.1[医药卫生—呼吸系统]