Clinical-radiomics combination model for predicting the short-term efficacy of bipolar transurethral enucleation of the prostate in patients with benign prostatic hyperplasia  

作　　者：Tianyou Zhang Zijun Mo Jiayu Huang Jun Wang Yiran Tao Lei Ye Wenwen Zhong Bing Yao Hu Qu Bo Ma Dejuan Wang Jiahui Mo Chunwei Ye Junying Zhu Jianguang Qiu 

机构地区：[1]Department of Urology,The Sixth Affiliated Hospital,Sun Yat-sen University,Guangzhou,China [2]Department of Urology,Biomedical lnnovation Center,The Sixth Affiliated Hospital,Sun Yat-sen University,Guangzhou,China [3]State Key Laboratory of Oncology in South China,Collaborative Innovation Center for CancerMedicine,Sun Yat-sen University Cancer Center,Guangzhou,China [4]Department of Urology,The First Affiliated Hospital,Sun Yat-sen University,Guangzhou,China [5]Department of Urology,The Second Affiliated Hospital of Kunming Medical University,Kunming,China [6]Department of Radiology,The Sixth Affiliated Hospital,Sun Yat-sen University,Guangzhou,China

出　　处：《Current Urology》2025年第1期30-38,共9页当代泌尿学(英文)

基　　金：supported by a grant from the Basic and Applied Basic Research Foundation of Guangdong Province,China(grant no.2019A1515010386).

摘　　要：Background:Bipolar transurethral enucleation of the prostate(B-TUEP)is a well-established surgical treatment for benign prostatic hyperplasia(BPH);however,its efficacy may vary depending on patient characteristics.Magnetic resonance imaging(MRI)with radiomics analysis can offer comprehensive and quantitative information about prostate characteristics that may relate to surgical outcomes.This study aimed to explore the value of MRI and radiomics analysis in predicting the short-term efficacy of B-TUEP for BPH.Materials and methods:A total of 137 patients with BPH who underwent B-TUEP at 2 institutions were included.Radiological features were measured in the MRIs,and the radiomics score was developed from 1702 radiomics features extracted from the prostate and transitional zone regions of interest.Three prediction models were developed and validated based on clinical-radiological features,radiomic features,and their combinations.The models were evaluated using the area under the receiver operating characteristic curve,calibration curve,and decision curve analysis.Results:The combination model exhibited the highest area under curve in both the training set(0.838)and the external validation set(0.802),indicating superior predictive performance and robustness.Furthermore,the combination model demonstrated good calibration(p>0.05)and optimal clinical utility.The combination model indicated that a highermaximum urine flow rate,lower transitional zone index,and higher radiomics score were associated with an increased risk of poor efficacy.Conclusions:Magnetic resonance imaging with radiomic analysis can offer valuable insights for predicting the short-term efficacy of BTUEP in patients with BPH.A combination model based on clinical and radiomics features can assist urologists in making more precise clinical decisions.

关 键 词：Benign prostatic hyperplasia Radiomics Prediction model Surgical efficacy Transurethral enucleation of the prostate 

分 类 号：R73[医药卫生—肿瘤]