细菌纤维素功能化改性及其在医学领域的研究进展  

Functional modification of bacterial cellulose and its research progress in the medical field

作　　者：陈琳元 张艺兵 李杰 陈静 黎庆涛[1] CHEN Linyuan;ZHANG Yibing;LI Jie;CHEN Jing;LI Qingtao(College of Light Industry and Food Engineering,Guangxi University,Nanning 530004,China)

机构地区：[1]广西大学轻工与食品工程学院,南宁530004

出　　处：《功能材料》2025年第2期2074-2083,共10页Journal of Functional Materials

基　　金：广西自然科学基金(2022GXNSFAA035578)。

摘　　要：细菌纤维素(bacterial cellulose,BC)具有独特的三维网络结构,其孔隙率高、机械强度大、生物相容性好,可作为人造血管、组织工程以及伤口敷料的理想候选者,是生物医学材料研究的热点之一。然而,由于BC本身并不具备抗菌、生肌止血等特点,限制了其在医学领域的进一步应用。因此,通过非原位和原位改性方法将功能性聚合物、碳基纳米材料以及金属纳米颗粒引入BC,获得具有增强功能特性的复合材料,这些改性的BC材料在该领域中展现出巨大的应用潜力。本综述介绍了BC的制备,及其功能化改性,并总结近年来其在医疗领域的主要成果,为开发低成本、绿色安全和多功能的医用材料提供参考。Bacterial cellulose has a unique three-dimensional network structure with high porosity,mechanical strength and good biocompatibility,which is beneficial for cell growth.It can be an ideal candidate for artificial blood vessels,tissue engineering,and wound excipients,and as well as one of the hotspots in biomedical material research.However,due to the fact that BC itself does not possess functional characteristics such as antibacterial,myogenic,and hemostatic properties,its further application in the medical field is limited.Therefore,by introducing functional polymers,carbon based nanomaterials,and metal nanoparticles into BC through ex-situ and in-situ modification methods,composite materials with enhanced functional properties are obtained.The modified BC materials have shown great potential for application in this field.This review provides a detailed introduction to the preparation and functionalization modification of BC,and summarizes its main achievements in the medical field in recent years,providing reference for the development of low-cost,green,safe,and multifunctional medical materials.

关 键 词：细菌纤维素 生物合成 功能化改性 医学应用 

分 类 号：R318.08[医药卫生—生物医学工程]