具有pH响应性的Cu/ZIF-8@Cur纳米颗粒的制备及抗菌性能研究  

Preparation and antibacterial properties of pH responsive Cu/ZIF-8@Cur nanoparticles

作　　者：曾凡行 徐畅[2] 董旭峰[1] 齐民[1] 庄熙晶 ZENG Fanxing;XU Chang;DONG Xufeng;QI Min;ZHUANG Xijin(School of Materials Science&Engineering,Dalian University of Technology,Dalian 116024,China;Central Hospital of Dalian University of Technology,Dalian 116089,China)

机构地区：[1]大连理工大学材料科学与工程学院,辽宁大连116024 [2]大连理工大学附属中心医院,辽宁大连116089

出　　处：《功能材料》2025年第2期2091-2098,共8页Journal of Functional Materials

基　　金：中央高校基本科研业务费项目(2023YGZD03)。

摘　　要：姜黄素是一类天然多酚,具有优异的抗菌性能,但是其稳定性低、溶解度差且在人体中代谢过快等缺点严重限制应用。基于此,研究采用一锅法设计并合成了一种铜掺杂的ZIF-8双金属MOF材料用于姜黄素的高效负载(简写为Cu/ZIF-8@Cur),以实现优异的抗菌性。首先,通过紫外和红外等分析,证明了姜黄素的成功负载,其负载率高达45.6%,且具有良好的稳定性。其次,通过实验验证了该复合颗粒具有优异的pH响应性:在未产生细菌时(中性条件),表现出良好的稳定性;当人体产生细菌(环境变为弱酸性),Cu/ZIF-8@Cur颗粒会缓慢的释放离子及药物。Cu/ZIF-8@Cur颗粒对大肠杆菌以及金黄葡萄球菌表现出优异的抗菌性,具备良好的应用前景。Curcumin is a kind of natural polyphenol with excellent antibacterial properties,but its low stability,poor solubility and rapid metabolism in human body severely limit its application.Based on this,a Cu-doped ZIF-8 bimetallic MOF material was designed and synthesized by a one-pot method for the efficient loading of curcumin(Cu/ZIF-8@Cur)in order to achieve excellent antibacterial properties.Firstly,through UV and IR,curcumin was loaded successfully.Its drug loading efficiency was up to 45.6%,and it had good stability.Secondly,we verified that the composite particle had excellent pH response.When no bacteria were produced(neutral condition),it showed good stability.When the body produced bacteria,the environment became slightly acidic,Cu/ZIF-8@Cur particles slowly released ions and drugs.Cu/ZIF-8@Cur particles showed excellent antibacterial activity against Escherichia coli and Staphylococcus aureus,and had a good application prospect.

关 键 词：抗菌 姜黄素 金属-有机框架 PH响应性 纳米颗粒 

分 类 号：TB34[一般工业技术—材料科学与工程]