尿酸对于老年急性冠状动脉综合征的预测研究  

Prediction of uric acid for elderly patients with acute coronary syndrome

作　　者：王新宇 陈牧雷[1] 刘宏斌[2] 李惟铭[1] 王洪江 王欣[1] 刘佳[1] 袁玉婷[1] 王娟[1] Wang Xinyu;Chen Mulei;Liu Hongbin;Li Weiming;Wang Hongjiang;Wang Xin;Liu Jia;Yuan Yuting;Wang Juan(Department of Cardiology,Beijing Chaoyang Hospital Affiliated to Capital Medical University,Beijing 100020,China)

机构地区：[1]首都医科大学附属北京朝阳医院心内科,100020 [2]解放军总医院第二医学中心心血管内科

出　　处：《中华老年心脑血管病杂志》2025年第3期290-293,共4页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：国家自然科学基金(81900382);北京市自然科学基金(7222072)。

摘　　要：目的探索尿酸对于老年急性冠状动脉综合征患者的心血管事件的预测作用。方法选取2017年6月至2022年10月北京朝阳医院心脏中心和解放军总医院第一医学中心门诊或住院患者3440例纳入研究,并完成随访观察,根据是否发生心血管事件分为心血管事件组529例和非心血管事件组2911例,收集患者临床资料,采用Cox风险比例回归分析。结果心血管事件组尿酸明显高于非心血管事件组(P<0.01)。在调整传统危险因素和血浆指标后,尿酸可显著预测临床终点事件(HR=2.634,95%CI:1.870~3.744,P<0.01)、心血管事件(HR=1.508,95%CI:1.357~1.660,P<0.01)发生,并且与急性心功能不全、心血管死亡、全因死亡显著相关(P<0.01)。结论尿酸为老年急性冠状动脉综合征心血管事件风险预测因子,为老年急性冠状动脉综合征患者提供重要早期急性心血管事件预警信息和诊断价值。Objective To investigate the predictive value of uric acid for cardiovascular events in the elderly patients with ACS.Methods An observational follow-up study was conducted on 3440 ACS inpatients and outpatients admitted in the Heart Center of Beijing Chaoyang Hospital and the First Medical Center of Chinese PLA General Hospital from June 2017 to October 2022.According to the occurrence of cardiovascular events,they were divided into a cardiovascular event group(529 patients)and a non-cardiovascular event group(291l patients).Their clinical data were collected for Cox risk proportional regression analysis.Results The cardiovascular event group had significantly uric acid when compared with the non-cardiovascular event group(P<0.01).After adjusting the traditional risk factors and plasma biomarkers,uric acid was still a significant predictor for clinical endpoints(HR=2.634,95%CI:1.870-3.744,P<0.01)and for cardiovascular events(HR=1.508,95%CI:1.357-1.660,P<0.01).Furthermore,uric acid was significantly correlated with acute heart failure,cardiovascular death and all-cause death(P<0.01).Conclusion Uric acid is a risk predictor for cardiovascular events in elderly ACS patients,and can provide early warning information and diagnostic value for acute cardiovascular events.

关 键 词：尿酸 冠状动脉疾病 心肌梗死 预测 

分 类 号：R541.4[医药卫生—心血管疾病]