呼吸道合胞病毒感染的免疫致病机制研究进展  

Research Progress on the Immuno-pathogenesis of Respiratory Syncytial Virus Infection

作　　者：张心悦[1] 吴芳[1] 聂晶 张瑶 虞念成 唐兰芳[3] ZHANG Xinyue;WU Fang;NIE Jing;ZHANG Yao;YU Niancheng;TANG Lanfang(Department of TCM,Children's Hospital,Zhejiang Unioersity School of Medicine,National Clinical Research Center for Child Health,Hangzhou 310052,China;Department of Pharmacy,Children's Hospital,Zhejiang University School of Medicine,National Clinical Research Center for Child Health,Hanzhou 310052,China;Department of Respiratory,Children's Hospital,Zhejiang University School of Medicine,National Clinical Research Center for Child Health,Hangzhou 310052,China)

机构地区：[1]浙江大学医学院附属儿童医院中医科,国家儿童健康临床研究中心,杭州310052 [2]浙江大学医学院附属儿童医院药剂科,国家儿童健康临床研究中心,杭州310052 [3]浙江大学医学院附属儿童医院呼吸科,国家儿童健康临床研究中心,杭州310052

出　　处：《病毒学报》2025年第1期222-231,共10页Chinese Journal of Virology

基　　金：浙江省科技计划项目(项目号:2023C03042),题目:中医优势病种中医药诊治新技术研究-儿童支气管哮喘的中西医诊治研究;国家中医药管理局科技司-浙江省中医药管理局共建科技计划重大项目(项目号:GZY-ZJ-KJ-24035),题目:和解法防治儿童急性呼吸道传染病的临床疗效评价研究;国家自然科学基金资助项目(项目号:82070028),题目:剪切起源的circRNA对气道黏蛋白MUC5AC调控在哮喘发病中的作用和机制研究;浙江省中医药科技计划项目(项目号:2024ZL601),题目:益气活血消腺方治疗儿童腺样体肥大气虚血瘀证的前瞻性观察性真实世界研究。

摘　　要：呼吸道合胞病毒(Respiratory syncytial virus,RSV)感染被认为是支气管哮喘(Bronchial asthma,BA)的一个重要病因。当RSV感染机体后,固有免疫、适应性免疫、肺气道上皮活化释放炎症介质、神经通路功能障碍等都可能发展为慢性病,影响气道发育,导致气管高反应性,诱发BA。本文简要介绍RSV的结构,RSV对固有免疫、适应性免疫、免疫系统、肺气道上皮活化及神经元等途径诱发BA的免疫致病机制,为防治RSV感染诱发BA提供参考。Respiratory syncytial virus(RSV)infection is considered a significant cause of bronchial asthma(BA).When RSV infects the body,various mechanisms such as the innate immunity,adaptive immunity,activation of pulmonary airway epithelium,leading to the release of inflammatory mediators,dysfunction of neural pathways and other factors,these may evolve into chronic diseases,affecting airway development,leading to airway hyper-responsiveness and inducing BA.This article briefly provides the structure of RSV,the immuno-pathogenic mechanisms by which RSV induces BA through pathways such as innate immunity,adaptive immunity,immune system,pulmonary airway epithelial activation and neurons.It aims to offer insights for prevention and treatment of RSV infection induced BA.

关 键 词：呼吸道合胞病毒 感染 哮喘 免疫机制 

分 类 号：R373.1[医药卫生—病原生物学] R725.6[医药卫生—基础医学]