人乳头瘤病毒核酸检测方法及应用  

Human Papillomavirus Nucleic Acid Detection Methods and Applications

作　　者：陈子玉 李慧莹[2] 张晓光[2] 李淑英 CHEN Ziyu;LI Huiying;ZHANG Xiaoguang;LI Shuying(Hebei Key Laboratory for Chronic Diseases,North China University of Science and Technology Basic Medical College,Tangshan 06300,China;National Institute for Viral Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 102206,China)

机构地区：[1]华北理工大学基础医学院,河北省慢性疾病基础医学重点实验室,唐山063000 [2]中国疾病预防控制中心病毒病预防控制所,北京102206

出　　处：《病毒学报》2025年第1期245-256,共12页Chinese Journal of Virology

基　　金：河北省自然基金中医药联合基金培育项目(项目号:H2022209048),题目:外泌体运载蚯蚓纤溶酶抗肿瘤机制的研究。

摘　　要：高危型人乳头瘤病毒(High-risk human papillomavirus,HR-HPV)持续感染可引起宫颈上皮内瘤样病变(Cervical intraepithelial neoplasia,CIN)和宫颈癌的发生。除细胞学检查外,HPV核酸检测是WHO推荐用于宫颈癌初筛的首选方法。HR-HPV核酸检测的引入可以提高CIN2+的检出率和宫颈癌筛查方案的效率。本文旨在对目前HPV核酸检测方法进行归纳总结,为宫颈癌筛查计划提供参考。Persistent infection with high-risk human papillomavirus(HR-HPV)is a major cause of cervical intraepithelial neoplasia(CIN)and cervical cancer.HR-HPV nucleic acid testing is recommended by WHO as the preferred method for primary cervical cancer screening.The adoption of HR-HPV testing can enhance the detection rate of CIN2+lesions and improve the efficiency of cervical cancer screening programs.This review aims to summarize the current methods for HPV nucleic acid detection s and provide a reference for cervical cancer screening strategies.

关 键 词：人乳头瘤病毒 宫颈癌 分子检测 

分 类 号：R373.9[医药卫生—病原生物学] R737.33[医药卫生—基础医学]