妊娠期糖尿病合并HBV感染与妊娠结局研究进展  

Research Progress on the Study of Gestational Diabetes Mellitus Combined with HBV Infection and Pregnancy Outcomes

作　　者：李维丹 石小霞[1] 何竞月 LI Weidan;SHI Xiaoxia;HE Jingyue(The First Affiliated Hospital of Nanyang Medical College of Higher Education,Nanyang 473000,China)

机构地区：[1]南阳医学高等专科学校第一附属医院,南阳473000

出　　处：《病毒学报》2025年第1期257-263,共7页Chinese Journal of Virology

摘　　要：妊娠期糖尿病(Gestational diabetes mellitus,GDM)是一种常见的妊娠期并发症,血糖控制不佳可导致早产、新生儿窒息等不良妊娠结局。乙型肝炎病毒(Hepatitis B virus,HBV)感染是临床常见的传染性疾病,越来越多研究证实HBV可影响肝脏对糖脂的代谢与调节,降低机体免疫力,参与GDM疾病的发生与发展,导致更严重的不良妊娠结局。因此对不良妊娠结局影响因素的把控有助于管理GDM合并HBV感染的疾病进程并改善妊娠结局。本研究综述了GDM合并HBV感染孕妇不良妊娠结局的影响因素及其免疫细胞因子表达的研究成果,以期为临床防治GDM合并HBV感染提供参考价值。Gestational diabetes mellitus(GDM)is a common complication of pregnancy,and inadequate glycemic control can lead to adverse outcomes such as preterm birth and neonatal asphyxia.Hepatitis B virus(HBV)infection,a frequently encountered infectious disease in clinical practice,has been increasingly implicated in altered hepatic glucose and lipid metabolism,reduced immune function,and the pathogenesis of GDM,thereby exacerbating adverse pregnancy outcomes.Identifying and controlling the factors influencing these adverse outcomes is essential for managing the disease course and improving pregnancy outcomes in women with GDM and HBV co-infection.This review summarizes current research on the factors that affect pregnancy outcomes and on alterations in immune cytokine expression in pregnant women with GDM and HBV infection,with the aim of providing valuable guidance for the clinical prevention and management of GDM complicated by HBV infection.

关 键 词：妊娠期糖尿病 乙型肝炎病毒 妊娠结局 影响因素 免疫细胞因子 

分 类 号：R373.2[医药卫生—病原生物学] R714.256[医药卫生—基础医学]