膀胱颈电切及注射曲胺耐德联合甲泼尼龙治疗膀胱颈挛缩临床价值研究  

Clinical value of bladder neck resection and injection of triamcinolone acetonide combined with methylprednisolone in the treatment of bladder neck contracture

作　　者：何问理 温海东 刘辉 林文俊 王森富 吴家根 He Wenli;Wen Haidong;Liu Hui;Lin Wenjun;Wang Senfu;Wu Jiagen(Department of Urology,The Third Affiliated Hospital of Sun Yat-sen University Yuedong Hospital,Meizhou 514700,China)

机构地区：[1]中山大学附属第三医院粤东医院泌尿外科,广东梅州514700

出　　处：《中华腔镜泌尿外科杂志(电子版)》2025年第1期58-62,共5页Chinese Journal of Endourology(Electronic Edition)

摘　　要：目的研究膀胱颈电切及注射曲安奈德联合甲泼尼龙片治疗膀胱颈挛缩的临床效果。方法纳入2019年1月至2022年1月期间我院收治的71例膀胱颈挛缩患者作为研究对象,按2020年1月开展进行了膀胱颈注射曲安奈德联合甲泼尼龙片为时间节点将患者分为两组。对照组35例患者仅采用经尿道膀胱颈部电切术治疗,观察组36例患者在对照组基础上加用曲安奈德注射联合甲泼尼龙片口服治疗。观察两组患者尿流量情况,包括最大尿流率及平均尿流率。采用国际前列腺症状评分量表(IPSS)评估两组患者手术前后症状情况。采用生活质量评分量表(QOL)评估两组患者手术前后生活质量情况。并随访患者12个月,观察两组患者复发情况。结果术前两组最大尿流率和平均尿流率对比差异无统计学意义(P>0.05),术后观察组最大尿流率和平均尿流率均高于对照组,差异有统计学意义(P<0.05)。术前两组IPSS、QOL评分对比差异无统计学意义(P>0.05);术后,观察组IPSS和QOL评分均低于对照组,差异有统计学意义(P<0.05)。随访12个月,观察组复发率5.56%明显低于对照组17.14%,差异有统计学意义(P<0.05)。结论膀胱颈电切及注射曲安奈德联合甲泼尼龙片能有效改善膀胱颈挛缩患者的临床症状,提高生活质量,且术后复发率较低,值得临床应用及推广。Objective To investigate the clinical efficacy of bladder neck electrocautery and injection of Triamcinolone Acetonide combined with Methylprednisolone tablets in the treatment of bladder neck contracture.Methods A total of 71 patients with bladder neck contracture admitted to our hospital from January 2019 to January 2022 were included as the research subjects.Patients were divided into two groups according to the time point of bladder neck injection of Triamcinolone Acetonide combined with Methylprednisolone tablets conducted in January 2020.The control group of 35 patients only received transurethral bladder neck resection,while the observation group of 36 patients received additional treatment with injection of Triamcinolone Acetonide combined with oral Methylprednisolone tablets on the basis of the control group.The maximum and average urine flow rates of the patients were observed.The International Prostate Symptom Score Scale(IPSS)was used to evaluate the symptoms of two groups of patients before and after surgery.The Quality of Life Rating Scale(QOL)was used to evaluate the quality of life of two groups of patients before and after surgery.Follow up with patients for 12 months to observe the recurrence status of both groups of patients.Results There was no statistically significant difference in the maximum and average urinary flow rates between the two groups before surgery(P>0.05).After surgery,the maximum and average urinary flow rates in the observation group were higher than those in the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in IPSS and QOL scores between the two groups before surgery(P>0.05);After surgery,the IPSS and QOL scores of the observation group were lower than those of the control group,and the difference was statistically significant(P<0.05).After a 12-month follow-up,the recurrence rate in the observation group was significantly lower at 5.56%compared to the control group at 17.14%,with a statistically sign

关 键 词：膀胱颈切除术 曲安奈德 甲泼尼龙 糖皮质激素 膀胱颈挛缩 

分 类 号：R47[医药卫生—护理学]