妊娠期高血压孕妇血清SerpinB1、SFRP5水平及与妊娠结局的关系  

The levels ofserum SerpinB1 and SFRP5 of pregnant women with gestational hypertension and their association with pregnancy outcomes

作　　者：许旭 江楠 李洁 何云 XU Xu;JIANG Nan;LI Jie;HE Yun(Department of Gynaecology and Obstetrics,Qingdao Women and Children’s Hospital,Shandong Qingdao 266000,China;Department of Obstetrics,Qingdao Women and Children’s Hospital,Shandong Qingdao 266000,China)

机构地区：[1]青岛市妇女儿童医院妇产科,山东青岛266000 [2]青岛市妇女儿童医院产科,山东青岛266000

出　　处：《中国妇幼健康研究》2025年第3期30-35,共6页Chinese Journal of Woman and Child Health Research

摘　　要：目的探讨妊娠期高血压疾病(HDP)孕妇血清分泌型卷曲相关蛋白5(SFRP5)、丝氨酸蛋白酶抑制剂B1(SerpinB1)水平,以及二者与妊娠结局的关系。方法选取2020年6月至2022年6月于青岛市妇女儿童医院就诊的132例HDP孕妇作为研究组,另选取140例同一时期孕检的健康孕妇作为对照组,采用酶联免疫吸附法(ELISA)检测血清两组SerpinB1、SFRP5水平。依据妊娠结局将研究组孕妇分为良好组(n=106)和不良组(n=26)。Logistic回归分析影响HDP孕妇发生不良妊娠结局的相关因素;受试者工作特征(ROC)曲线评估血清SerpinB1、SFRP5水平对HDP孕妇发生妊娠不良结局的预测价值。结果研究组孕妇初产、吸烟史、酗酒史、孕妇子痫前期史、子痫前期家族史所占比例及甘油三酯、收缩压、舒张压、血清SerpinB1均高于对照组,血清SFRP5低于对照组,差异有统计学意义(χ^(2)/t值介于2.866~30.978之间,P<0.05);研究组孕妇胎膜早破、羊水异常、宫缩乏力发生率均高于对照组,差异有统计学意义(χ^(2)值分别为11.005、4.686、4.306,P<0.05);HDP孕妇妊娠结局良好组收缩压、舒张压、血清SerpinB1均低于不良组,血清SFRP5高于不良组,差异有统计学意义(t值介于2.581~6.453之间,P<0.05);Logistic回归结果显示血清SerpinB1为影响HDP孕妇发生不良结局的危险因素,SFRP5是保护因素(OR值分别为3.328、0.618,P<0.05);血清SerpinB1、SFRP5及二者联合预测HDP孕妇发生不良妊娠结局的曲线下面积(AUC)分别为0.775、0.879、0.968,二者联合优于血清SerpinB1、SFRP5各自单独预测(Z值分别为3.866、2.372,P<0.05)。结论HDP孕妇血清SerpinB1水平显著升高,血清SFRP5水平显著降低,二者与孕妇妊娠结局联系密切,且二者联合对HDP孕妇发生妊娠不良结局有一定的预测价值。Objective To investigate the levels of serum secreted frizzle-associated protein 5(SFRP5)and serine protease inhibitor B1(SerpinB1)in pregnant women with gestational hypertension(HDP)and their relationship with pregnancy outcomes.Methods A total of 132 pregnant women with HDP who were admitted to Qingdao Women and Children s Hospital from June 2020 to June 2022 were collected as the study group,and 140 healthy pregnant women with pregnancy tests at the same period were selected as the control group.Enzyme linked immunosorbent assay(ELISA)was applied to detect the expression levels of SerpinB1 and SFRP5 in serum.According to the pregnancy outcomes,pregnant women in the study group were divided into good group(n=106)and poor group(n=26).Logistic regression analysis was performed to analyze the factors affecting adverse pregnancy outcomes in pregnant women with HDP.The receiver operating characteristic(ROC)curve evaluated the predictive value of serum SerpinB1 and SFRP5 levels in adverse pregnancy outcomes in pregnant women with HDP.Results The proportions of primiparity,smoking history,alcoholism history,preeclampsia history,preeclampsia family history,triglyceride,systolic blood pressure,diastolic blood pressure and serum SerpinB1 in the study group were higher than those in the control group,and the serum SFRP5 was lower than that in the control group,and the differences were statistically significant(χ^(2)/t values were between 2.866~30.978,P<0.05).The incidences of premature rupture of membranes,abnormal amniotic fluid and uterine atony in the study group were higher than those in the control group,and the differences were statistically significant(χ^(2)=11.005,4.686,4.306,P<0.05).The systolic blood pressure,diastolic blood pressure and serum SerpinB1 in the good pregnancy outcome group were lower than those in the poor pregnancy outcome group,and the serum SFRP5 was higher than that in the poor pregnancy outcome group,and the differences were statistically significant(t values were between 2.581 and 6.453,P<

关 键 词：妊娠期高血压疾病 丝氨酸蛋白酶抑制剂B1 分泌型卷曲相关蛋白5 妊娠结局 

分 类 号：R173[医药卫生—妇幼卫生保健]