血清bFGF、IFN-γ水平检测对儿童病毒性脑炎的临床诊断价值  

The clinical diagnostic value of serum bFGF and IFN-γlevels in children with viral encephalitis

作　　者：张娜 李静[1] 闫晓静 张岚 刘伟霄[3] ZHANG Na;LI Jing;YAN Xiaojing;ZHANG Lan;LIU Weixiao(Department of PediatricsⅢ,Xingtai People s Hospital,Hebei Xingtai 054000,China;Department of Neurology,Xingtai General Hospital of North China Medical and Health Group,Hebei Xingtai 054000,China;Department of Pediatrics,Xingtai People s Hospital,Hebei Xingtai 054000,China)

机构地区：[1]邢台市人民医院儿三科,河北邢台054000 [2]华北医疗健康集团邢台总医院神经内科,河北邢台054000 [3]邢台市人民医院儿科,河北邢台054000

出　　处：《中国妇幼健康研究》2025年第3期60-65,共6页Chinese Journal of Woman and Child Health Research

基　　金：河北省卫生和计划生育委员会科研基金项目(20201586);邢台市重点研发计划自筹项目(2021ZC138)。

摘　　要：目的通过检测病毒性脑炎患儿血清中碱性成纤维细胞生长因子(bFGF)、干扰素γ(IFN-γ)水平,分析bFGF、IFN-γ与病情严重程度的关系及对儿童病毒性脑炎的诊断效能。方法选取2019年7月至2020年12月邢台市人民医院儿科收治的病毒性脑炎患儿57例作为病毒组,并根据严重程度分为轻型(33例,轻病毒组)、中型(15例,中病毒组)、重型(9例,重病毒组),另取正常体检儿童43例为对照组。通过检测血清bFGF、IFN-γ水平,分析各组中bFGF、IFN-γ水平差异。Pearson相关法分析血清bFGF与IFN-γ水平相关性。受试者工作特征(ROC)曲线分析血清bFGF、IFN-γ对儿童病毒性脑炎的诊断价值。结果与对照组相比,病毒组血清bFGF、IFN-γ水平均升高,差异有统计学意义(t值分别为5.700、7.234,P<0.05);轻病毒组、中病毒组、重病毒组bFGF、IFN-γ水平依次升高,差异有统计学意义(F值分别为9.554、10.967,P<0.05);Pearson相关法分析显示,病毒组血清bFGF与IFN-γ水平呈正相关性(r=0.528,P<0.001);受试者工作特征(ROC)曲线分析显示,血清bFGF、IFN-γ水平及二者联合诊断病毒性脑炎的曲线下面积(AUC)分别为0.784(95%CI:0.694~0.874)、0.878(95%CI:0.812~0.944)、0.910(95%CI:0.853~0.967);血清bFGF、IFN-γ水平及二者联合检测病毒性脑炎患儿,与临床诊断标准相比Kappa值分别为0.479、0.620、0.609,P<0.05。结论病毒性脑炎患儿血清bFGF、IFN-γ水平升高,bFGF与IFN-γ呈正相关性,bFGF、IFN-γ联合有助于临床诊断儿童病毒性脑炎。Objective By detecting the levels of basic fibroblast growth factor(bFGF)and interferon-gamma(IFN-γ)in the serum of children with viral encephalitis,this study analyzes the relationship between bFGF,IFN-γ,and the severity of the condition,as well as the diagnostic efficacy of bFGF and IFN-γfor pediatric viral encephalitis.Methods A total of 57 children diagnosed with viral encephalitis and admitted to the Department of Pediatrics,Xingtai People s Hospital,from July 2019 to December 2020 were enrolled as the viral encephalitis group.Based on disease severity,they were further classified into the mild(33 cases,mild viral group),moderate(15 cases,moderate viral group),and severe(9 cases,severe viral group)subgroups.Additionally,43 healthy children undergoing routine physical examinations were included as the control group.Serum bFGF and IFN-γlevels were measured and compared among groups.The correlation between serum bFGF and IFN-γlevels was analyzed using Pearson correlation analysis.The diagnostic value of serum bFGF and IFN-γfor viral encephalitis was evaluated using receiver operating characteristic(ROC)curve analysis.Results Compared with the control group,serum bFGF and IFN-γlevels were significantly elevated in the viral encephalitis group(t=5.700 and 7.234,respectively,P<0.05).Serum bFGF and IFN-γlevels increased progressively from the mild to the moderate and severe viral encephalitis subgroups,with statistically significant differences(F=9.554 and 10.967,respectively,P<0.05).Pearson correlation analysis showed a positive correlation between serum bFGF and IFN-γlevels in the viral encephalitis group(r=0.528,P<0.001).Receiver operating characteristic(ROC)curve analysis revealed that the area under the curve(AUC)for serum bFGF,IFN-γ,and their combined diagnosis of viral encephalitis were 0.784(95%CI:0.694-0.874),0.878(95%CI:0.812-0.944),and 0.910(95%CI:0.853-0.967),respectively.The Kappa values comparing serum bFGF,IFN-γ,and their combined detection with clinical diagnostic standards were 0.479,0.6

关 键 词：病毒性脑炎 儿童 碱性成纤维细胞生长因子 干扰素Γ 

分 类 号：R179[医药卫生—妇幼卫生保健]