布地格福联合乙酰半胱氨酸雾化吸入治疗COPD的效果分析  

Analysis of the effect of budgefu combined with acetylcysteine nebulization inhalation in the treatment of COPD

作　　者：杨子琦 杨向意 钟燕 YANG Zi-qi;YANG Xiang-yi;ZHONG Yan(Department of General Medicine,Ganzhou People's Hospital,Ganzhou 341000,Jiangxi;Emergency Department of Ganzhou People's Hospital,Ganzhou 341000,Jiangxi)

机构地区：[1]赣州市人民医院全科医学科,江西赣州341000 [2]赣州市人民医院急诊科,江西赣州341000

出　　处：《安徽医专学报》2025年第1期25-27,共3页Journal of Anhui Medical College

摘　　要：目的:探讨布地格福、乙酰半胱氨酸雾化吸入在慢性阻塞性肺疾病(COPD)中的应用效果。方法:依据随机数表法将医院收治的92例COPD患者分成两组,各46例。对照组接受乙酰半胱氨酸雾化吸入,实验组加用布地格福,比较两组治疗效果、症状改善情况、肺功能、炎性指标及不良反应。结果:实验组患者的治疗总有效率高于对照组(P<0.05);实验组患者咳痰、呼吸困难、咳嗽及肺部哮鸣音缓解时间短于对照组(P<0.05);实验组患者治疗后FEV_(1)、MVV、FVC水平高于对照组,IL-17、IL-18与TNF-α水平低于对照组(P<0.05);实验组患者不良反应率较对照组略高,但差异无统计学意义(P>0.05)。结论:布地格福、乙酰半胱氨酸联合用于COPD中安全有效,能抑制炎性反应,提升肺功能,促使症状缓解。Objective:Exploring the application effect of Budgefu and Acetylcysteine nebulization inhalation in chronic obstructive pulmonary disease(COPD).Method:According to the random number table method,92 COPD patients admitted to the hospital were divided into two groups,with 46 patients in each group.The control group received nebulized inhalation of acetylcysteine,while the experimental group received budesonide based on the control group.The treatment effects,symptom improvement,lung function,inflammatory indicators,and adverse reactions were compared between the two groups.Result:Compared with the control group,the experimental group had a higher total effective rate(P<0.05);Compared with the control group,the experimental group had a shorter relief time for cough,dyspnea,cough,and lung wheezing(P<0.05);Compared with the control group,the experimental group had higher levels of FEV_(1),MVV,and FVC after treatment,and lower levels of IL-17,IL-18,and TNF-α(P<0.05);The incidence of adverse reactions in the experimental group was slightly higher than that in the control group,but there was no significant difference(P>0.05).Conclusion:The combination of budesonide and acetylcysteine is safe and effective in COPD,which can inhibit inflammatory reactions,improve lung function,and promote symptom relief.

关 键 词：慢性阻塞性肺疾病 布地格福 乙酰半胱氨酸 肺功能 

分 类 号：R563.9[医药卫生—呼吸系统]