睡眠剥夺中前额叶功能与过度觉醒的关系:脑电图频谱与微状态分析研究  

Association between prefrontal function and hyperarousal in sleep deprivation:Electroencephalogram spectral and microstate analyses

作　　者：何佳秀 程金湘 赵显超 宿长军 HE Jiaxiu;CHENG Jinxiang;ZHAO Xianchao(Department of Neurology,Tangdu Hospital,Air Force Medical University&Fourth Military Medical University,Xi’an 710000,China)

机构地区：[1]空军军医大学(第四军医大学)唐都医院神经内科,陕西西安710000

出　　处：《中风与神经疾病杂志》2025年第2期165-170,共6页Journal of Apoplexy and Nervous Diseases

摘　　要：目的研究睡眠剥夺条件下前额叶皮质(PFC)功能与过度觉醒之间的关系。方法采用脑电图(EEG)研究睡眠剥夺中PFC与过度觉醒的关系。分析源自南方医院开源数据库“睡眠剥夺静息态脑电图数据集”的数据。运用功率谱密度(PSD)和微状态分析对比正常睡眠与睡眠剥夺期间的脑功能活动。结果分析对象为37名参与者的清醒静息态EEG(NS)后37次记录及睡眠剥夺24 h后37次记录。与NS相比,睡眠剥夺后所有脑区及PFC的PSD值升高。与NS相比,睡眠剥夺后4种微状态的持续时间和频率降低,而4种状态的覆盖范围在NS与睡眠剥夺间无显著变化。结论本研究表明PFC的过度觉醒在睡眠剥夺中起关键作用,良好睡眠助于缓解过度觉醒。Objective Investigate the association between prefrontal cortex(PFC)function and hyperarousal in sleep deprivation.Methods EEG was used to investigate the association between PFC and hyperarousal in sleep deprivation.The data from the open-source database of A Resting-state EEG Dataset for Sleep Deprivation from Nanfang Hospital were analyzed,and the PSD analysis and the microstate analysis were used to compare brain functional activity during NS and sleep deprivation.Results The resting-state EEG data after awakening were collected from 37 participants,including 37 recordings after NS and 37 recordings after sleep deprivation for 24 hours.Compared with NS,there were increases in PSD values of all brain regions and PFC after sleep deprivation.Compared with NS,there were reductions in the duration and frequency of four microstates after sleep deprivation,while there were no significant changes in the coverage of the four states between NS and sleep deprivation.Conclusion This study shows that hyperarousal in PFC plays an important role in sleep deprivation,and good sleep can help to alleviate hyperarousal.

关 键 词：睡眠剥夺 脑电图 微状态分析 功率谱密度 前额叶皮质 

分 类 号：R338.63[医药卫生—人体生理学]