肺癌患者合并肺栓塞的相关因素分析  

Analysis of related factors in lung cancer patients with pulmonary embolism

作　　者：黄宝丽 吴林珂[1] 张琦婉 徐青[1] 吴琪[1] 张凯[1] 陶钰[1] Huang Baoli;Wu Linke;Zhang Qiwan;Xu Qing;Wu Qi;Zhang Kai;Tao Yu(Department of Respiratory and Critical Care Medicine,Nanjing Affiliated Hospital,Nanjing Medical University(Nanjing First Hospital),Nanjing 210006,Jiangsu,China)

机构地区：[1]南京医科大学附属南京医院(南京市第一医院)呼吸与危重症医学科,江苏南京210006

出　　处：《血管与腔内血管外科杂志》2025年第1期76-79,共4页Journal of Vascular and Endovascular Surgery

基　　金：国家自然科学基金委员会资助项目(81903089)。

摘　　要：目的 探讨肺癌患者发生肺栓塞的相关因素。方法 收集2019年4月至2024年4月在南京医科大学附属南京医院(南京市第一医院)住院接受诊治的102例肺癌患者的临床资料,按照肺栓塞发生情况将其分为观察组(n=15,发生肺栓塞)与对照组(n=87,未发生肺栓塞),分析肺癌患者发生肺栓塞的相关因素。结果 观察组患者年龄、老年(≥60岁)比例、指尖脉氧饱和度<97%比例、入院时D-二聚体(D-D)升高(>0.5 mg/L)比例、肺癌分期Ⅲ~Ⅳ期比例均高于对照组患者,差异均有统计学意义(P<0.05)。多因素分析结果显示,老年(≥60岁)、指尖脉氧饱和度<97%、入院时D-D升高(>0.5 mg/L)以及肺癌分期Ⅲ~Ⅳ期均是肺癌患者发生肺栓塞的独立危险因素(P<0.05)。结论 老年(≥60岁)、指尖脉氧饱和度<97%、D-D升高(>0.5 mg/L)以及肺癌分期Ⅲ~Ⅳ期均是肺癌患者发生肺栓塞的危险因素,临床中应根据这些因素及时识别高危患者并积极给予预防性治疗。Objective To investigate the related factors of pulmonary embolism in patients with lung cancer.Method Clinical data of 102 patients with lung cancer who were h1ospitalized in Nanjing Affiliated Hospital,Nanjing Medical University(Nanjing First Hospital)from April 2019 to April 2024 were collected.According to the occurrence of pulmonary embolism,they were divided into observation group(n=15,pulmonary embolism occurred)and control group(n=87,no pulmonary embolism occurred).The related factors of pulmonary embolism in lung cancer patients were analyzed.Result In observation group,the age,the proportion of old age(age≥60 years),fingertip pulse oxygen saturation<97%,D-dimer(D-D)increased(>0.5 mg/L)at admission,and lung cancer stage III to IV were higher than those in control group,with statistical significance(P<0.05).The results of multivariate analysis showed that old age(≥60 years old),fingertip pulse oxygen saturation<97%,D-D increased(>0.5 mg/L)and stageⅢ-Ⅳof lung cancer were independent risk factors for pulmonary embolism in lung cancer patients(P<0.05).Conclusion Old age(age≥60 years old),fingerfinger pulse oxygen saturation<97%,D-D increased(>0.5 mg/L)and stage III-IV of lung cancer are all risk factors for pulmonary embolism in lung cancer patients.In clinical practice,high-risk patients should be timely identified according to these factors and preventive treatment should be actively given.

关 键 词：肺癌 肺栓塞 因素 

分 类 号：R543[医药卫生—心血管疾病]