沙米茎秆和沙米全粉饼干对肥胖模型大鼠的减肥效果研究  

Study on the weight loss effect of Agriophyllum Squarrosum stem and whole powder biscuits on obese model rats

作　　者：贾孝荣 张桂芳 徐贵静 史亚丽 史彦斌[2] JIA Xiaorong;ZHANG Guifang;XU Guijing;SHI Yali;SHI Yanbin(Gansu Dazhengxing Health Management Co.,Ltd,Lanzhou,Gansu,730050,China;School of Pharmacy,Lanzhou University,Lanzhou,Gansu,730000,China)

机构地区：[1]甘肃大整行健康管理有限公司,甘肃兰州730050 [2]兰州大学药学院,甘肃兰州730000

出　　处：《甘肃中医药大学学报》2025年第1期14-19,共6页Journal of Gansu University of Chinese Medicine

基　　金：甘肃省兰州市人才创新创业项目(2019-RC-44)。

摘　　要：目的评价沙米茎秆和沙米全粉饼干对肥胖模型大鼠的减肥效果。方法以高脂饲料喂饲SD大鼠,建立大鼠肥胖模型。将实验大鼠随机分为空白对照组、模型对照组、燕麦魔芋组、沙米全粉组、沙米茎秆组5组,每组8只。空白对照组予维持饲料喂饲,其余4组分别予高脂饲料、燕麦魔芋饼干、沙米全粉饼干、沙米茎秆饼干与维持饲料混合制备的饲料喂饲。测量、计算大鼠体质量、颈围、腰围、Lee’s指数、脂体比、肝脏指数;酶法测定大鼠血清甘油三酯(TG)、胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)水平;HE染色,镜下观察大鼠肝、肾组织病理变化。结果高脂饲料喂饲至第5周,与空白对照组比较,各造模组大鼠体质量增长率明显升高,差异均有统计学意义(P<0.05)。实验第5,15周,与空白对照组比较,模型对照组大鼠TC、LDL-C水平明显升高,HDL-C水平明显降低,差异均有统计学意义(P<0.05);实验第15周,沙米茎秆组大鼠TC、LDL-C水平明显低于模型对照组及沙米全粉组,差异均有统计学意义(P<0.05)。与空白对照组比较,模型对照组大鼠的颈围和腰围明显增大,Lee’s指数及脂体比明显升高,差异均有统计学意义(P<0.05);与模型对照组比较,沙米全粉组、沙米茎秆组、燕麦魔芋组大鼠的颈围和腰围无明显变化,差异均无统计学意义(P>0.05),但沙米茎秆组大鼠Lee’s指数与脂体比明显低于模型对照组及沙米全粉组,差异均有统计学意义(P<0.05)。沙米茎秆组大鼠肝脏脂肪病变程度较模型对照组轻。结论沙米茎秆饼干具有一定的减肥、保肝和调脂作用,而沙米全粉饼干不具有减肥作用。Objective To evaluate the weight loss effects of Agriophyllum squarrosum stem and whole powder biscuits on obese model rats.Methods High-fat diet was used to feed SD rats to establish the rat obesity model.The experimental rats were randomly divided into five groups:blank control group,model control group,oat konjac group,Agriophyllum squarrosum whole powder group,and Agriophyllum squarrosum stem group,with 8 rats in each group.The blank control group was fed with maintenance diet,while the other four groups were fed with high-fat diet,oat konjac biscuits,whole powder biscuits of Agriophyllum squarrosum,and stem biscuits of Agriophyllum squarrosum mixed with maintenance diet.The body weight,neck circumference,waist circumference,Lee's index,fat-to-body ratio,and liver index of the rats were measured and calculated.The levels of triglyceride(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),and high-density lipoprotein cholesterol(HDL-C)in the serum of the rats were determined by enzymatic method.HE staining was used to observe the pathological changes of liver and kidney tissues under a microscope.Results By the fifth week of administering a high-fat diet,the body weight growth rate of rats in each model group exhibited a notable increase compared to the blank control group,with these differences being statistically significant(P<0.05).At both the fifth and fifteenth weeks of the experiment,the mo-del control group demonstrated marked elevations in TC and LDL-C levels,along with a significant reduction in HDL-C levels,compared to the blank control group.These disparities were statistically significant(P<0.05).At the fifteenth week,the Agriophyllum squarrosum stem group exhibited significantly lower TC and LDL-C levels than both the model control group and the Agriophyllum squarrosum whole powder group,with these differences being statistically significant(P<0.05).When compared to the blank control group,the model control group showed substantial increases in neck and waist circumference,as well

关 键 词：肥胖 沙米全粉 沙米茎秆 减肥 降脂 保肝 大鼠 实验研究 

分 类 号：R285.5[医药卫生—中药学]