二甲双胍联合盐酸吡格列酮治疗2型糖尿病合并冠心病的效果分析  

Analysis on Effect of Metformin Combined with Pioglitazone Hydrochloride in Treatment of Type 2 Diabetes Mellitus Complicated with Coronary Heart Disease

作　　者：任敏英 孙登昆[2] Ren Minying;Sun Dengkun(Pharmacy of Chunshu Community Health Service Center in Xicheng District,Beijing 100052,China;Department of Pharmacy,Xuanwu Hospital,Capital Medical University,Beijing 100053,China)

机构地区：[1]北京市西城区椿树社区卫生服务中心药房,北京100052 [2]首都医科大学宣武医院药剂科,北京100053

出　　处：《中国社区医师》2025年第5期27-29,共3页Chinese Community Doctors

摘　　要：目的:分析二甲双胍联合盐酸吡格列酮治疗2型糖尿病(T2DM)合并冠心病的效果。方法:选取2023年1—12月首都医科大学宣武医院收治的T2DM合并冠心病患者90例作为研究对象,随机分为对照组和联合组,每组45例。对照组给予盐酸吡格列酮治疗,联合组在对照组基础上给予二甲双胍治疗。比较两组治疗效果。结果:治疗后,两组空腹血糖、餐后2 h血糖、糖化血红蛋白水平低于治疗前,且联合组低于对照组(P<0.05)。治疗后,两组甘油三酯、总胆固醇水平低于治疗前,且联合组低于对照组(P<0.05)。治疗后,两组冠状动脉狭窄程度评分低于治疗前,且联合组低于对照组(P<0.001)。结论:二甲双胍联合盐酸吡格列酮治疗T2DM合并冠心病的效果显著,可降低血糖和血脂指标,改善冠状动脉狭窄状况。Objective:To analyze the effect of metformin combined with pioglitazone hydrochloride in the treatment of type 2 diabetes mellitus(T2DM)complicated with coronary heart disease.Methods:From January 2023 to December 2023,a total of 90 patients with T2DM complicated with coronary heart disease admitted to Xuanwu Hospital of Capital Medical University were selected as the study subjects.They were randomly divided into control group and combination group,with 45 cases in each group.The control group was treated with pioglitazone hydrochloride and the combination group was treated with metformin on the basis of control group.The therapeutic effects of the two groups were compared.Results:After treatment,the fasting blood glucose,2 h postprandial blood glucose and glycated hemoglobin levels in two groups were lower than those before treatment,and the levels in the combination group were lower than those in the control group(P<0.05).After treatment,the levels of triglycerides and total cholesterol in two groups were lower than those before treatment,and the levels in the combination group were lower than those in the control group(P<0.05).After treatment,the scores of coronary stenosis in two groups were lower than those before treatment,and the scores in the combination group were lower than those in the control group(P<0.001).Conclusion:Metformin combined with pioglitazone hydrochloride is effective in the treatment of T2DM complicated with coronary heart disease,and can decrease the blood glucose and blood lipid indicators,and improve the coronary stenosis.

关 键 词：2型糖尿病 冠心病 二甲双胍 盐酸吡格列酮 

分 类 号：R587.1[医药卫生—内分泌] R541.4[医药卫生—内科学]