瑞安市健康体检人群血清抗甲状腺过氧化物酶抗体、内脂素及尿碘水平与甲状腺结节的相关性  

Correlation between serum TPOAb,visfatin,urinary iodine levels and thyroid nodules in individuals undergoing physical examinations in Ruian city

作　　者：叶小珍 朱瑞锷 孙芳红 YE Xiaozhen;ZHU Ruie;SUN Fanghong(Department of Ultrasound Imaging,Ruian People’s Hospital,Wenzhou 325200,China;Department of Chronic Disease,Ruian Center for Disease Control and Prevention,Wenzhou 325200,China)

机构地区：[1]瑞安市人民医院超声影像科,浙江温州325200 [2]瑞安市疾病预防控制中心慢病科,浙江温州325200

出　　处：《温州医科大学学报》2025年第3期213-217,共5页Journal of Wenzhou Medical University

摘　　要：目的:探讨瑞安市体检人群血清抗甲状腺过氧化物酶抗体(TPOAb)、内脂素及尿碘水平与甲状腺结节(TN)的相关性。方法:选取2021年6月至2023年12月期间于瑞安市人民医院健康管理体检中心行甲状腺超声检查的600例体检者,并根据超声检查结果将受检者分为TN组(n=340)和无TN组(n=260)。采用尿碘串联质谱(ICP-MS)法测量受检者尿碘水平,并根据结果分为碘缺乏、碘适宜和碘过量。采用化学发光法测定血清TPOAb水平,ELISA检测血清内脂素水平;多因素Logistic回归分析TN发生的影响因素。结果:TN组患者年龄、BMI、TG、血清促甲状腺激素(TSH)、抗甲状腺球蛋白抗体(TGAb)、TPOAb和内脂素水平高于无TN组(P<0.05)。TN组碘缺乏检出率为38.82%(132/340),碘适宜检出率为38.82%(132/340),碘过量检出率为22.35%(76/340);无TN组碘缺乏检出率为33.85%(88/260),碘适宜检出率为52.31%(136/260),碘过量检出率为13.85%(36/260),两组间差异有统计学意义(χ^(2)=12.705,P<0.05)。多因素Logistic回归分析结果显示,年龄、BMI及TG、TSH、TGAb、TPOAb、内脂素和尿碘水平为TN发生的影响因素(均P<0.05)。结论:瑞安市健康体检人群中,TN患者血清TPOAb、内脂素水平均明显升高,TN患者与无TN患者尿碘水平有明显差异,TPOAb、内脂素水平升高以及尿碘水平过高或过低均可能会增加TN发生的风险。Objective:To explore the correlation between serum levels of anti-thyroid peroxidase antibody(TPOAb),visfatin,urinary iodine and thyroid nodules(TN)in the individuals undergoing physical examination in Ruian city.Methods:Six hundred individuals who underwent thyroid ultrasound examination at the Health Management Examination Center of Ruian People’s Hospital between June 2021 and December 2023 were included,who were assigned as TN group(n=340)and TN free group(n=260)based on the ultrasound examination results.The urine iodine tandem mass spectrometry(ICP-MS)method was applied to measure the urine iodine level of subjects,who were subdivided into iodine deficiency group(n=220),iodine moderate group(n=268),and iodine excess group(n=112)based on the results.Chemiluminescence method was applied to determine serum TPOAb level.ELISA was used to detect serum visfatin level.Multivariate Logistic regression was applied to analyze the influencing factors of TN occurrence.Results:Compared with TN-free group,patients in the TN group had older age and higher BMI,TG,TSH,TGAb,TPOAb,and endostatin levels(P<0.05).In TN group,the detection rate of iodine deficiency was 38.82%(132/340),the detection rate of iodine appropriacy was 38.82%(132/340),and the detection rate of iodine excess was 22.35%(76/340),while in the TN-free group,the detection rate of iodine deficiency was 33.85%(88/260),the detection rate of iodine appropriacy was 52.31%(136/260),and the detection rate of iodine excess was 13.85%(36/260),showing statistical significance between the two groups(χ^(2)=12.705,P<0.05).The results of multivariate Logistic regression analysis showed that age,BMI and levels of TG,TSH,TGAb,TPOAb,endolipids and urinary iodine were the influencing factors for TN occurrence(all P<0.05).Conclusion:Based on the health examination population in Ruian city,this study found that the serum levels of TPOAb and visfatin were significantly increased in TN patients and there’s significant difference in urinary iodine level between TN patients and

关 键 词：甲状腺结节 甲状腺过氧化物酶抗体 内脂素 尿碘 

分 类 号：R581[医药卫生—内分泌]