肺部超声联合血清指标对儿童社区获得性肺炎的临床诊断价值  

Clinical diagnostic value of lung ultrasound combined with serum indicators for pediatric community-acquired pneumonia

作　　者：赵佳宝 张松林[2] 王慧敏[1] ZHAO Jiabao;ZHANG Songlin;WANG Huimin(Department of Ultrasound Medicine,Children′s Hospital Affiliated to Zhengzhou University,Zhengzhou Children′s Hospital of Henan Children′s Hospital,Zhengzhou,Henan,450018;Department of Respiratory Medicine,Children′s Hospital Affiliated to Zhengzhou University,Zhengzhou Children′s Hospital of Henan Children′s Hospital,Zhengzhou,Henan,450018)

机构地区：[1]郑州大学附属儿童医院/河南省儿童医院郑州儿童医院超声医学科,河南郑州450018 [2]郑州大学附属儿童医院/河南省儿童医院郑州儿童医院呼吸科,河南郑州450018

出　　处：《实用临床医药杂志》2025年第3期104-107,113,共5页Journal of Clinical Medicine in Practice

基　　金：河南省医学科技攻关计划联合共建项目(LHGJ20190919)。

摘　　要：目的探讨肺部超声(LUS)联合血清白细胞介素(IL)-1β、IL-12p70对儿童社区获得性肺炎(CAP)的临床诊断价值。方法选取136例疑似CAP患儿作为研究对象,以胸部计算机断层扫描(CT)检查结果为金标准,将患儿分为CAP组95例和非CAP组41例。观察并比较2组患儿入院时LUS特征、LUS评分及血清IL-1β、IL-12p70水平;绘制受试者工作特征(ROC)曲线,分析LUS联合血清IL-1β、IL-12p70对CAP的诊断效能。结果CAP组患儿间质性疾病、胸膜线异常、胸腔积液、肺实变、支气管征的发生率均高于非CAP组,差异有统计学意义(P<0.05);CAP组患儿血清IL-1β、IL-12p70水平及LUS评分均高于非CAP组,差异有统计学意义(P<0.05);ROC曲线分析结果显示,入院时LUS评分联合血清IL-1β、IL-12p70诊断CAP的曲线下面积为0.981,敏感度为93.68%,特异度为95.12%,诊断效能显著高于各指标单独诊断(P<0.05)。结论LUS联合血清IL-1β、IL-12p70对儿童CAP具有较高的诊断价值。Objective To investigate the clinical diagnostic value of lung ultrasound(LUS)combined with serum interleukin(IL)-1βand IL-12p70 for pediatric community-acquired pneumonia(CAP).Methods A total of 136 pediatric patients with suspected CAP were enrolled and divided into CAP group(95 patients)and non-CAP group(41 patients)based on chest computed tomography(CT)results as the gold standard.The LUS characteristics,LUS scores,serum levels of IL-1βand IL-12p70 were compared between the two groups at admission.Receiver operating characteristic(ROC)curves were plotted to analyze the diagnostic efficacy of LUS combined with serum IL-1βand IL-12p70 for CAP.Results The incidence rates of interstitial disease,pleural line abnormalities,pleural effusion,lung consolidation,and bronchial signs were higher in the CAP group than those in the non-CAP group(P<0.05).The serum levels of IL-1β,IL-12p70 and LUS scores were also higher in the CAP group than in the non-CAP group(P<0.05).ROC curve analysis showed that the area under the curve for the diagnosis of CAP using LUS scores combined with serum IL-1βand IL-12p70 at admission was 0.981,with a sensitivity of 93.68%,a specificity of 95.12%,and a diagnostic efficacy was significantly higher than that of each index alone(P<0.05).Conclusion LUS combined with serum IL-1βand IL-12p70 has high diagnostic value for pediatric CAP.

关 键 词：社区获得性肺炎 肺部超声 白细胞介素-1Β 白细胞介素-12p70 诊断效能 

分 类 号：R563.1[医药卫生—呼吸系统] R445[医药卫生—内科学] R446[医药卫生—临床医学]