正常眼压性青光眼患者血清基质细胞衍生因子-1、趋化因子受体7及视盘区血管密度与临床分期的相关性  

Correlations of serum stromal cell-derived factor-1,chemokine receptor 7 and vascular density in the optic disc area with clinical stages in patients with normal-tension glaucoma

作　　者：王萍 刘建荣 喻磊 马丽芬 肇莉莉 WANG Ping;LIU Jianrong;YU Lei;MA Lifen;ZHAO Lili(Ophthalmology Department,Xi′an Municipal People′s Hospital of Shaanxi Province,Xi′an,Shaanxi,710000)

机构地区：[1]陕西省西安市人民医院眼科,陕西西安710000

出　　处：《实用临床医药杂志》2025年第4期1-5,共5页Journal of Clinical Medicine in Practice

基　　金：陕西省重点研发计划项目(2022SF-1062)。

摘　　要：目的探讨正常眼压性青光眼(NTG)患者血清基质细胞衍生因子-1(SDF-1)、趋化因子受体7(CXCR7)及视盘区血管密度与临床分期的相关性。方法选取157例NTG患者为NTG组,根据不同临床分期分为Ⅰ期组(n=29)、Ⅱ期组(n=88)和Ⅲ期组(n=40);另选取56例同期健康体检者为对照组。比较NTG组与对照组血清SDF-1、CXCR7水平;分析不同临床分期患者视盘区血管密度变化;采用多因素Logistic回归分析探讨NTG的危险因素。结果与对照组比较,NTG组血清SDF-1、CXCR7水平升高,差异有统计学意义(P<0.05)。与对照组比较,NTG组患者大血管密度、毛细血管密度、全区域血管密度降低,无血管区密度升高,差异有统计学意义(P<0.05);Ⅱ期组、Ⅲ期组毛细血管密度、全区域血管密度低于Ⅰ期组,无血管区密度高于Ⅰ期组,差异有统计学意义(P<0.05)。大血管密度(r=-0.503,P=0.006)、毛细血管密度(r=-0.546,P<0.001)、全区域血管密度(r=-0.553,P<0.001)与临床分期呈负相关,无血管区密度与临床分期呈正相关(r=0.521,P=0.002)。NTG组高血压、饮酒史、青光眼家族史以及血清SDF-1高水平、CXCR7高水平患者比率高于对照组,差异有统计学意义(P<0.05)。多因素Logistic回归分析显示,高血压、青光眼家族史、饮酒史以及高血清SDF-1、CXCR7水平是NTG发生的危险因素(P<0.05)。结论NTG患者血清SDF-1、CXCR7水平显著升高,大血管密度、毛细血管密度、全区域血管密度与患者临床分期呈负相关,无血管区密度与临床分期呈正相关。血清SDF-1、CXCR7可作为NTG诊断和临床分期的有效参考指标。Objective To investigate the correlations of serum stromal cell-derived factor-1(SDF-1),chemokine receptor 7(CXCR7)and vascular density in the optic disc area with clinical stages in patients with normal-tension glaucoma(NTG).Methods A total of 157 patients with NTG were included in the NTG group and divided into stageⅠgroup(n=29),stageⅡgroup(n=88),and stageⅢgroup(n=40)based on different clinical stages;additionally,56 healthy individuals with physical examinations in the same period were selected as control group.Serum SDF-1 and CXCR7 levels were compared between the NTG group and the control group;changes in vascular density in the optic disc area among patients with different clinical stages were analyzed;the multivariate Logistic regression analysis was conducted to explore the risk factors for NTG.Results Compared with the control group,the NTG group had significantly increased serum levels of SDF-1 and CXCR7(P<0.05).Compared with the control group,patients in the NTG group showed significantly decreased densities of large vessels,capillaries,and the entire area,as well as significantly increased density of avascular areas(P<0.05).The densities of capillaries and the entire area were significantly lower in the stageⅡgroup and stageⅢgroup than the stageⅠgroup,while the density of avascular areas was significantly higher(P<0.05).The densities of large vessels(r=-0.503,P=0.006),capillaries(r=-0.546,P<0.001),and the entire area(r=-0.553,P<0.001)were negatively significantly correlated with clinical stages,while the density of avascular area was positively significantly correlated with clinical stages(r=0.521,P=0.002).The proportions of patients with hypertension,history of alcohol consumption,family history of glaucoma,and high serum levels of SDF-1 and CXCR7 in the NTG group were significantly higher than those in the control group(P<0.05).Multivariate Logistic regression analysis revealed that hypertension,family history of glaucoma,history of alcohol consumption,and high serum levels of SDF-1 and

关 键 词：正常眼压性青光眼 血清基质细胞衍生因子-1 趋化因子受体7 视盘区血管密度 临床分期 

分 类 号：R828.7[医药卫生—临床医学] R276.7R319