妊娠期糖尿病患者血清赛宁-25、激活素A表达水平与妊娠结局的关系  

Relationships of serum Xenin-25 and activin A expression levels with pregnancy outcome in patients with gestational diabetes mellitus

作　　者：权永娟 邓海娟 李芬 QUAN Yongjuan;DENG Haijuan;LI Fen(Obstetrics Department,Weinan Central Hospital of Shaanxi Province,Weinan,Shaanxi,714000)

机构地区：[1]陕西省渭南市中心医院产科,陕西渭南714000

出　　处：《实用临床医药杂志》2025年第4期55-59,共5页Journal of Clinical Medicine in Practice

基　　金：陕西省科技计划项目(2019SF-357);陕西省渭南市2019年度科技项目重点研发计划项目(2019ZDYF-JCYJ-132)。

摘　　要：目的探讨妊娠期糖尿病(GDM)患者血清赛宁-25(Xenin-25)、激活素A(activin A)表达水平与妊娠结局的关系。方法选取2020年12月-2023年2月本院收治的269例GDM孕妇为研究对象,检测血清Xenin-25、activin A水平,记录妊娠结局。根据妊娠结局的不同将GDM患者分为妊娠结局不良组(91例)和妊娠结局良好组(178例)。分析GDM患者不良妊娠结局的影响因素以及Xenin-25、activin A预测GDM妊娠结局的价值。结果妊娠结局不良组年龄、孕前体质量指数(BMI)、不良孕产史占比以及空腹血糖(FPG)、糖化血红蛋白(HbA1c)、activin A水平高于妊娠结局良好组,血清Xenin-25水平低于妊娠结局良好组,差异有统计学意义(P<0.05)。高HbA1c与高activin A水平是GDM患者妊娠结局的危险因素(P<0.05),高Xenin-25是妊娠结局的保护因素(P<0.05)。Xenin-25、activin A预测GDM患者不良妊娠结局的曲线下面积分别为0.895、0.865,二者联合预测的曲线下面积为0.981,高于Xenin-25或activin A单独预测(P<0.05)。结论GDM患者血清Xenin-25、activin A与不良妊娠结局有关,可作为妊娠结局预测的标志物。Objective To investigate the relationships of serum levels of Xenin-25 and activin A with pregnancy outcomes in patients with gestational diabetes mellitus(GDM).Methods A total of 269 pregnant women with GDM admitted to our hospital between December 2020 and February 2023 were enrolled.Serum levels of Xenin-25 and activin A were measured,and pregnancy outcomes were recorded.Based on pregnancy outcomes,patients were divided into poor pregnancy outcome group(91 cases)and good pregnancy outcome group(178 cases).The influencing factors of adverse pregnancy outcomes of GDM patients and the predictive value of Xenin-25 and activin A for GDM pregnancy outcomes were analyzed.Results The poor pregnancy outcome group had higher age,pre-pregnancy body mass index(BMI),proportion of adverse obstetric history,as well as levels of fasting plasma glucose(FPG),glycated hemoglobin(HbA1c),and activin A compared to the good pregnancy outcome group,and serum level of Xenin-25 was lower in the poor pregnancy outcome group(P<0.05).High HbA1c and high activin A levels were identified as risk factors for pregnancy outcomes in GDM patients,while high Xenin-25 was a protective factor for pregnancy outcomes(P<0.05).The areas under the curve(AUCs)for predicting adverse pregnancy outcomes in GDM patients using Xenin-25 and activin A were 0.895 and 0.865,respectively,while the AUC for combined prediction was 0.981,which was higher than that of Xenin-25 or activin A alone(P<0.05).Conclusion Xenin-25 and activin A in GDM patients are associated with adverse pregnancy outcomes and can serve as biomarkers for predicting pregnancy outcomes.

关 键 词：妊娠期糖尿病 不良妊娠结局 血糖控制 血清赛宁-25 激活素A 

分 类 号：R714.256[医药卫生—妇产科学] R587.1[医药卫生—临床医学] R446.11