转移相关基因家族与宫颈癌关系的研究进展  

Research progress in relationship between metastasis-associated gene family and cervical cancer

作　　者：吕佳玟 卢丹[1,2] LYU Jiawen;LU Dan(Northern Jiangsu People′s Hospital Affiliated to Yangzhou University,Yangzhou,Jiangsu,225001;School of Medicine of Yangzhou University(Institute of Translational Medicine),Yangzhou,Jiangsu,225001)

机构地区：[1]扬州大学附属苏北人民医院,江苏扬州225001 [2]扬州大学医学院(转化医学研究院),江苏扬州225001

出　　处：《实用临床医药杂志》2025年第4期129-133,共5页Journal of Clinical Medicine in Practice

基　　金：国家自然科学基金项目(82072088)。

摘　　要：宫颈癌是原发于子宫颈部位的恶性肿瘤,其是女性生殖道最常见的恶性肿瘤。近年来,随着对肿瘤机制的深入研究,肿瘤形成和转移信号通路中的关键调控因子一一被发现,其中转移相关基因(MTA)是一类新发现的肿瘤进展相关基因家族。研究证明,MTA家族与妇科恶性肿瘤的发生密切相关,但针对宫颈癌的相关性研究尚少。本文对MTA家族与宫颈癌之间的关系进行阐述,以明确其在宫颈癌发生与发展中的作用,从而为宫颈癌的预防、诊断、预后评估和治疗提供新的视角。Cervical cancer is a malignant tumor that originates in the cervix of the uterus,which is the most common malignant tumor in the female reproductive tract.In recent years,with the deepening understanding of tumor mechanisms,key regulatory factors in tumor formation and metastasis signaling pathways have been identified.Among these,the metastasis-associated gene(MTA)family represents a newly discovered group of genes associated with tumor progression.Studies have demonstrated that the MTA family is closely related to the development of gynecological malignancies;however,research specifically addressing its association with cervical cancer remains limited.This review aimed to elucidate the relationship between the MTA family and cervical cancer,to clarify their roles in the initiation and progression of the disease,thereby providing new roles for the prevention,diagnosis,prognosis,and treatment of cervical cancer.

关 键 词：宫颈癌 转移相关基因 人乳头瘤病毒 宫颈上皮内瘤变 结构特点 妇科恶性肿瘤 

分 类 号：R711.74[医药卫生—妇产科学] R329.2[医药卫生—临床医学] R271.9