肿瘤坏死因子-α基因rs1800630多态性与Graves病易感性的Meta分析  

A Meta-analysis of the association between tumor necrosis factor-αgene rs1800630 polymorphism and susceptibility to Graves’disease

作　　者：孙玲玲 凌烈锋[1,2] 徐蕾 SUN Lingling;LING Liefeng;XU Lei(School of Basic Medical Sciences,Wannan Medical College,Wuhu 241002,Anhui,China;Anhui Key Laboratory of Active Biological Macromolecules,Wannan Medical College,Wuhu 241002,Anhui,China)

机构地区：[1]皖南医学院基础医学院,安徽芜湖241002 [2]皖南医学院活性生物大分子安徽省重点实验室,安徽芜湖241002

出　　处：《右江民族医学院学报》2025年第1期144-148,155,共6页Journal of Youjiang Medical University for Nationalities

基　　金：国家自然科学基金项目(32271287)。

摘　　要：目的探索肿瘤坏死因子-α基因rs1800630多态性与Graves病遗传易感性之间的关系。方法检索从建库至2023年12月PubMed、Web of Science、Embase、The Cochrane Library、中国生物医学文献数据库(CBM)、中国知网收集肿瘤坏死因子-α启动子rs1800630多态性与Graves病易感性的相关文献。采用Stata 15.0、RevMan 5.2软件进行Meta分析。结果8篇文献纳入Meta分析,包括2024例Graves病患者和2347例对照。Meta分析结果显示在显性模型[AA+CA/CC,OR=1.35,95%CI(1.07~1.70),P=0.01]及杂合子模型[CA/CC,OR=1.35,95%CI(1.08~1.70),P=0.01]及等位基因模型[A/C,OR=1.28,95%CI(1.04~1.58),P=0.02]下rs1800630多态与Graves病相关。亚组分析结果显示,仅在亚洲人群中该多态与Graves病发病具有统计学意义,显性模型OR=1.56,95%CI(1.28~1.91),P<0.001;杂合子模型OR=1.56,95%CI(1.26~1.93),P<0.001;等位基因模型OR=1.45,95%CI(1.22~1.71),P<0.001。结论TNF-α基因rs1800630多态位点与Graves病的易感性存在一定的关联,尤其在亚洲人群中A等位基因具有增加罹患Graves病的风险。Objective To explore the association between the tumor necrosis factor-α(TNF-α)gene rs1800630 polymorphism and genetic susceptibility to Graves’disease.Methods Relevant literature on the association between TNF-αpromoter rs1800630 polymorphism and Graves’disease susceptibility was retrieved from PubMed,Web of Science,Embase,The Cochrane Library,China Biology Medicine(CBM),and China National Knowledge Infrastructure(CNKI)from the establishment of the databases to December 2023.Meta-analysis was conducted using Stata 15.0 and RevMan 5.2 software.Results Eight studies involving 2024 Graves’disease patients and 2347 controls were included in the meta-analysis.The results showed that the rs1800630 polymorphism was associated with Graves’disease under the dominant model[AA+CA/CC,OR=1.35,95%CI(1.07~1.70),P=0.01],heterozygous model[CA/CC,OR=1.35,95%CI(1.08~1.70),P=0.01],and allele model[A/C,OR=1.28,95%CI(1.04~1.58),P=0.02].Subgroup analysis revealed that this polymorphism was significantly associated with Graves’disease only in the Asian population,with OR=1.56,95%CI(1.28~1.91),P<0.001 for the dominant model;OR=1.56,95%CI(1.26~1.93),P<0.001 for the heterozygous model;and OR=1.45,95%CI(1.22~1.71),P<0.001 for the allele model.Conclusion There is a certain association between the TNF-αgene rs1800630 polymorphic locus and susceptibility to Graves’disease.In particular,the A allele increases the risk of suffering from Graves’disease in the Asian population.

关 键 词：肿瘤坏死因子-Α 多态 GRAVES病 META分析 

分 类 号：R581.3[医药卫生—内分泌]