环泊酚在机器人辅助腹腔镜下根治性前列腺癌切除术中的应用  

Application of ciprofol in robot-assisted laparoscopic radical prostatectomy

作　　者：田芳芳 喻倩 李小雅 金淑敏 庄莹莹 TIAN Fangfang;YU Qian;LI Xiaoya;JIN Shumin;ZHUANG Yingying(Department of Anesthesiology,the Second Affiliated Hospital of Air Force Military Medical University,Xi’an 71000,China)

机构地区：[1]空军军医大学第二附属医院麻醉科,陕西西安710000

出　　处：《机器人外科学杂志(中英文)》2025年第2期256-259,共4页Chinese Journal of Robotic Surgery

基　　金：国家自然科学基金青年科学基金项目(81801391)。

摘　　要：目的:探究环泊酚在机器人辅助腹腔镜下根治性前列腺癌切除术(RARP)患者中的应用效果。方法:选取2020年2月-2023年8月空军军医大学第二附属医院行RARP的202例患者作为研究对象。依据麻醉方式不同将其分为研究组和对照组,每组101例。对照组给予七氟烷麻醉维持,研究组给予环泊酚麻醉维持。比较两组患者在T0(麻醉前5 min)、T1(插管后5 min)、T2(麻醉后1 h)、T3(术后2 h)时的脑氧饱和度、血流动力学指标、术后恢复情况及不良反应发生率。结果:T0时,两组患者脑氧饱和度无显著差异(P>0.05)。T1时,研究组脑氧饱和度显著高于对照组(P<0.05)。T2、T3时研究组脑氧饱和度显著低于对照组(P<0.05)。T1、T2、T3时,研究组HR、SBP、DBP显著低于对照组(P<0.05)。研究组患者呼吸恢复时间、睁眼时间、拔管时间、出室时间均显著快于对照组(P<0.05)。研究组发生不良反应7例(6.93%)显著低于对照组17例(16.83%)(P<0.05)。结论:环泊酚在RARP患者中能够维持脑氧饱和度的稳定,改善血流动力学,减少恢复时间,降低不良反应发生。Objective:To explore the effect of ciprofol in patients undergoing robot-assisted laparoscopic radical prostatectomy(RARP).Methods:202 patients who underwent RARP from February 2020 to August 2023 in the Second Affiliated Hospital of Air Force Military Medical University were selected and divided into the study group(ciprofol anesthesia maintenance,n=101)and the control group(sevoflurane anesthesia maintenance,n=101)according to different anesthesia maintenance methods.The cerebral oxygen saturation(rSO2),hemodynamic parameters,postoperative recovery,and incidence of adverse reactions at T0(5 minutes before anesthesia),T1(5 minutes after intubation),T2(1 hour after anesthesia),and T3(2 hours after surgery)were compared between the two groups of patients.Results:There was no significant difference in rSO_(2) between the two groups at T0(P>0.05).Compared to the control group,the rSO_(2) in the study group was significantly higher at T1(P<0.05)and lower at T2 and T3(P<0.05).The HR,SBP,and DBP at T1,T2,and T3 were significantly lower in the study group than those in the control group(P<0.05).The respiratory recovery time,eye-opening time,extubation time,and leaving time from recovery room were significantly shorter in the study group than those in the control group(P<0.05).The total incidence of adverse reactions was significantly lower in the study group(7 cases,6.93%)than that in the control group(17 cases,16.83%)(P<0.05).Conclusion:The use of ciprofol can stabilize the rSO2,improve hemodynamic parameters,reduce recovery time,and decrease the incidence of adverse reactions in patients undergoing RARP.

关 键 词：环泊酚 机器人辅助腹腔镜手术 根治性前列腺癌切除术 脑氧饱和度 血流动力学 

分 类 号：R693.5[医药卫生—泌尿科学]