Mass spectrometry imaging for unearthing and validating quality markers in traditional Chinese medicines  

作　　者：Zhiyun Wang Huajie Chang Qian Zhao Wenfeng Gou Yiliang Li Zhengwei Tu Wenbin Hou 

机构地区：[1]Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine,Institute of Radiation Medicine,Peking Union Medical College&Chinese Academy of Medical Sciences,Tianjin 300192,China [2]Tianjin Nankai District Wangdingdi Hospital,Tianjin 300190,China [3]Tianjin Key Laboratory of Acute Abdomen Disease Associated Organ Injury and ITCWM Repair,Tianjin NanKai Hospital,Tianjin 300100,China

出　　处：《Chinese Herbal Medicines》2025年第1期31-40,共10页中草药(英文版)

基　　金：sponsored by the National Natural Science Foundation of China(No.82303681&82202950);the Fundamental Research Funds for the Central Universities(No.3332022063);the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(No.2021-I2M-1-042)。

摘　　要：Quality marker(Q-Marker)is an innovative concept and model for quality control of Traditional Chinese medicines(TCMs),which will navigate the new direction of quality development of TCMs.Yet,how to characterize the overall quality attributes of TCMs and their biological effects is still debating.In view of this key scientific issue,this paper proposes a research method based on mass spectrometry imaging(MSI)technology for the discovery and confirmation of TCMs Q-Marker.MSI is powerful in investigating the spatial distribution of molecules in a variety of samples,and visualizing the information obtained from MS.On this basis,combine with the five principles of TCMs Q-Marker validation,i.e.,specificity,transmission and traceability,testability,prescription compatibility,and validity,were applied to confirm the finalized Q-Marker.It will lead the new direction of quality development of TCMs.

关 键 词：five principles quality marker quality control traditional Chinese medicines 

分 类 号：R284[医药卫生—中药学]