生物活性水凝胶通过调控细胞行为促进皮肤慢性创面愈合  

Bioactive Hydrogels Promote Skin Chronic Wound Healing Through Regulating Cell Behaviors

作　　者：谢梦恬 马雨龙 孙一榕 孙海[1] 许维国[1] 王国良 丁建勋[1,2] XIE Mengtian;MA Yulong;SUN Yirong;SUN Hai;XU Weiguo;WANG Guoliang;DING Jianxun(Key Laboratory of Polymer Ecomaterials,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China;School of Applied Chemistry and Engineering,University of Science and Technology of China,Hefei 230026,China)

机构地区：[1]中国科学院长春应用化学研究所中国科学院生态环境高分子材料重点实验室,长春130022 [2]中国科学技术大学应用化学与工程学院,合肥230026

出　　处：《材料导报》2025年第5期35-48,共14页Materials Reports

基　　金：国家自然科学基金(W2421115,U23A20591);吉林省科技发展计划项目(20240101002JJ);中国科学院青年创新促进会优秀会员(Y2023066)。

摘　　要：随着我国人口老龄化的加速,皮肤慢性创面的发病率持续上升。由于其愈合周期长且易复发,慢性创面不仅严重威胁患者的身心健康,也对我国医疗系统造成了沉重负担。慢性创面的愈合是一个涉及多种细胞和信号因子精密协作的复杂过程,因此单一的治疗手段,如抗炎治疗,难以有效应对这一多维生理过程。近年来,生物活性水凝胶凭借其优异的生物相容性、精准调控细胞行为以及调节信号因子释放的能力,在改善创面微环境、促进细胞增殖等方面表现出显著优势。本文系统阐述了生物活性水凝胶在皮肤创面修复过程中的作用机制,涵盖止血、抗炎、细胞增殖促进、胶原沉积及细胞外基质重塑等关键阶段。最后,本文展望了生物活性水凝胶在临床应用中的广阔前景,并针对当前在临床转化过程中面临的主要挑战和亟需解决的问题进行了深入探讨,为未来慢性创面修复相关的研究和技术开发提供参考。With the acceleration of population aging in China,the incidence of skin chronic wounds has been increasing steadily.Due to their prolonged healing cycles and high recurrence rates,chronic wounds not only pose significant threats to patients’physical and mental health but also impose a heavy burden on the healthcare system.The healing of chronic wounds is a complex process that involves the precise coordination of various cells and signaling factors,making it challenging for single therapeutic approaches,such as anti-inflammatory treatments,to effectively address this multifaceted physiological process.In recent years,bioactive hydrogels have demonstrated remarkable advantages in improving wound microenvironments and promoting cell proliferation due to their excellent biocompatibility,precise regulation of cell behaviors,and ability to modulate the release of signaling factors.This review systematically elucidates the mechanisms by which bioactive hydrogels contribute to skin wound healing,encompassing key stages,such as hemostasis,anti-inflammation,promotion of cell proliferation,collagen deposition,and extra-cellular matrix remodeling.Finally,the review explores the promising clinical applications of bioactive hydrogels while highlighting the major chal-lenges and unresolved issues in their clinical translation,providing references for future research and technological advancements in chronic wound healing.

关 键 词：钛合金-羟基磷灰石复合材料 制备工艺 羟基磷灰石 粉末冶金 搅拌摩擦焊接 

分 类 号：R751.05[医药卫生—皮肤病学与性病学] R758.7[医药卫生—临床医学]