中晚期结直肠癌患者术后化学治疗期间胃肠道症状发生情况及影响因素  

The incidence and influencing factors of gastrointestinal symptoms during postoperative chemotherapy in patients with advanced colorectal cancer

作　　者：何冯贤 周红飞[1] 解金凤[1] HE Fengxian;ZHOU Hongfei;XIE Jinfeng(Nantong Tumor Hospital,Nantong,Jiangsu,226361,China)

机构地区：[1]南通市肿瘤医院,江苏南通226361

出　　处：《中西医结合护理(中英文)》2025年第1期133-136,共4页Journal of Clinical Nursing in Practice

摘　　要：目的探讨中晚期结直肠癌患者在术后接受化学治疗(简称“化疗”)期间胃肠道症状发生情况,并分析其影响因素和总结护理方法。方法选取南通市肿瘤医院于2020年1月至2022年12月收治的136例中晚期结直肠癌患者,并回顾性分析其临床资料。所有患者均已接受结直肠癌手术治疗,通过自制的问卷调查分析表对患者的一般资料和生理指标进行调查和分析,采用单因素及Logistic回归模型分析其在术后化疗期间发生胃肠道症状的主要影响因素,并制定相应的护理对策。结果136例中晚期结直肠癌患者在术后化疗期间有84例患者发生胃肠道症状,发生率为61.76%。单因素分析显示,年龄、身体质量指数、术前营养状况、术前肠道症状、手术时间、术中出血量、腹水、心理状态以及合并其他并发症均与胃肠道症状的发生有关(P均<0.05)。多因素分析显示,年龄、术前营养状况、术前肠道症状、腹水以及合并其他并发症均是中晚期结直肠癌患者在术后化疗期间发生胃肠道症状的影响因素(P均<0.05)。结论中晚期结直肠癌患者在术后化疗期间发生胃肠道症状的风险较高,其中年龄、术前营养状况、术前肠道症状等均为其影响因素,临床需针对相关影响因素为患者制定针对性的护理措施。Objective To explore the occurrence of gastrointestinal symptoms in patients with advanced colorectal cancer during postoperative chemotherapy,and to analyze its influencing factors,and summarize nursing methods.Methods A total of 136 patients with advanced colorectal cancer admitted to Nantong Tumor Hospital from January 2020 to December 2022 were selected and their clinical data were retrospectively analyzed.All patients have undergone surgical treatment for colorectal cancer.A self-made questionnaire was used to investigate and analyze the general information and physiological indicators of the patients.Univariate and logistic regression models were used to analyze the main influencing factors of gastrointestinal symptoms during postoperative chemotherapy,and corresponding nursing strategies were formulated.Results Among 136 patients with advanced colorectal cancer,84 patients experienced gastrointestinal symptoms during postoperative chemotherapy,with an incidence rate of 61.76%.Univariate analysis showed that age,body mass index,preoperative nutritional status,preoperative intestinal symptoms,surgery time,intraoperative bleeding,ascites,psychological status,and other complications were all associated with the occurrence of gastrointestinal symptoms(all P<0.05).Multivariate analysis showed that age,preoperative nutritional status,preoperative intestinal symptoms,ascites,and other complications were all influencing factors for gastrointestinal symptoms during postoperative chemotherapy in patients with advanced colorectal cancer(all P<0.05).Conclusion Patients with advanced colorectal cancer have a higher risk of gastrointestinal symptoms during postoperative chemotherapy,among which age,preoperative nutritional status, and preoperative intestinal symptoms are all influencing factors.Clinically, targeted nursing measures should be developed for patients based on relevant influencingfactors.

关 键 词：中晚期结直肠癌 化学治疗 胃肠道症状 影响因素 护理对策 

分 类 号：R473.73[医药卫生—护理学]