解吸电喷雾电离-质谱成像技术快速鉴别化妆品类物证  

Rapid Distinguishment of Cosmetics as Physical Evidence by Desorption Electrospray Ionization-Mass Spectrometry Imaging Technology

作　　者：齐柔柔 何钦文 肖婷 吕小宝[2] 梁建英[1] 戴维[2] QI Rourou;HE Qinwen;XIAO Ting;LÜXiaobao;LIANG Jianying;DAI Wei(School of Pharmacy,Fudan University,Shanghai 201203,China;Identification Center of Evidential Materials,Shanghai Public Security Bureau,Shanghai 200083,China)

机构地区：[1]复旦大学药学院,上海201203 [2]上海市公安局物证鉴定中心,上海200083

出　　处：《理化检验(化学分册)》2025年第2期182-189,共8页Physical Testing and Chemical Analysis(Part B:Chemical Analysis)

基　　金：痕迹科学与技术公安部重点实验室开放课题(2020FMKFKT06)。

摘　　要：考虑到化妆品检测常用方法色谱法存在样品前处理复杂、会损耗样品、在化妆品物证中应用少等缺点,采用解吸电喷雾电离-质谱成像(DESI-MSI)技术检测不同种类、档次化妆品护手霜、防晒霜、粉底液,建立了相关质谱库,并用于化妆品以及指纹中化妆品的鉴别。用棉签点涂化妆品于双面胶上,制成点涂样品;用涂抹过化妆品的手指按压双面胶或按压桌面后用双面胶沾取桌面指纹,制成模拟指纹样品。在正离子模式下,采用DESI-MSI技术检测上述点涂样品和模拟指纹样品。结果显示:不同档次化妆品含有的原料不同,根据特有离子的MSI效果可区分化妆品档次;不同种类化妆品中化学成分不同,利用MSI可定性分析化妆品中具体成分;正品和仿制品中化学成分不同,根据质谱图差异和特有离子MSI效果差异可进行真伪鉴别;结合所建化妆品质谱库,可对未知化妆品进行鉴别;利用DESI-MSI技术可实现模拟指纹样品中化妆品的鉴别,且不受指纹完整性、指纹中内源性物质的影响。In consideration of the shortcomings of chromatography,a common method for cosmetics detection,such as complex sample pre-processing,sample loss,and limited application in cosmetic physical evidence,desorption electrospray ionization-mass spectrometry imaging(DESI-MSI)technology was used to detect different types and grades of cosmetics including hand cream,sunscreen,liquid foundation,and a related mass spectrometry library was established,which was used to identify cosmetics and cosmetics in fingerprints.A spot coating sample was prepared by applying cosmetics onto double-sided tape using a cotton swab.Simulated fingerprint samples were prepared by pressing the double-sided tape or picking up fingerprints from the desktop with the double-sided tape after pressing the fingerprint on the desktop with the fingers coated with cosmetics.In positive ion mode,DESI-MSI technology was used to detect the above-mentioned spot coating samples and simulated fingerprint samples.It was shown that different grades of cosmetics contained different raw materials,and the grade of cosmetics could be distinguished based on the MSI effect of unique ions.Different types of cosmetics had different chemical compositions,and MSI could be used for qualitative analysis of specific ingredients in cosmetics.Genuine and counterfeit products had different chemical compositions,and could be identified for authenticity based on differences in mass spectra and MSI effects of unique ions.Based on the established cosmetics mass spectrometry library,unknown cosmetics could be identified.DESI-MSI technology could achieve the identification of cosmetics in simulated fingerprint samples without being affected by fingerprint integrity and endogenous substances in the fingerprint.

关 键 词：化妆品 指纹 解吸电喷雾电离-质谱成像 物证检验 

分 类 号：O657.63[理学—分析化学]