PCN-250硅胶基质整体柱的制备及初步应用  

Preparation and preliminary application of PCN-250 silica gel matrix monolithic columns

作　　者：胡春奇 雷金鑫 陈默 高宇[1] 徐栖笛 王颖[1] 高立娣[1,2] 秦世丽 HU Chun-qi;LEI Jin-xin;CHEN Mo;GAO Yu;XU Xi-di;WANG Ying;GAO Li-di;QIN Shi-li(College of Chemistry and Chemical Engineering,Qiqihar University,Heilongjiang Qiqihar 161006,China;Technology Innovation Center of Industrial Hemp,State Administration for Market Regulation,Heilongjiang Qiqihar 161006,China)

机构地区：[1]齐齐哈尔大学化学与化学工程学院,黑龙江齐齐哈尔161006 [2]国家市场监管技术创新中心(工业大麻),黑龙江齐齐哈尔161006

出　　处：《齐齐哈尔大学学报(自然科学版)》2025年第2期75-79,共5页Journal of Qiqihar University(Natural Science Edition)

基　　金：黑龙江省教育厅基本科研业务专项(145209503)。

摘　　要：以正硅酸甲酯和甲基三甲氧基硅烷为硅胶基质前驱体,铁基金属有机骨架材料(PCN-250)为改性材料,采用溶胶凝胶法制备具有良好稳定性和优异分离性能的PCN-250硅胶基质毛细管整体柱。实验结果表明,该柱在10min内可以分离2种芳香族医药中间体、3种碱性氨基酸和4种尼泊金酯,分离性能良好。The PCN-250 silica gel matrix capillary monolithic column with good stability and excellent separation performance was prepared by the sol-gel method using methyl orthosilicate and methyltrimethoxysilane as silica gel matrix precursors and iron-based metal organoskeleton material(PCN-250)as a modified material.The experimental results showed that the column could separate two aromatic pharmaceutical intermediates,three basic amino acids and four nipagin esters within 10 min with good separation performance.

关 键 词：PCN-250 硅胶整体柱 毛细管电色谱 

分 类 号：O657.7[理学—分析化学]