氧合器用聚(4-甲基-1-戊烯)中空纤维膜的国内研究进展  

Domestic research progress of poly(4-methyl-1-pentene)hollow fiber membrane for oxygenators

作　　者：李孟璐 朱尘琪 郭晴 疏艳 郭媛 许剑 Li Menglu;Zhu Chenqi;Guo Qing;Shu Yan;Guo Yuan;Xu Jian(RocketMedical Co.,Ltd.,Beijing 100079,China)

机构地区：[1]航天新长征医疗器械(北京)有限公司,北京100079

出　　处：《现代仪器与医疗》2025年第1期88-95,共8页Modern Instruments & Medical Treatment

基　　金：中国航天科技集团自主研发项目(2023002、2023003)。

摘　　要：体外膜式氧合器(Extracorporeal Membrane Oxygenation,ECMO)是一种体外生命支持技术,常用于为心肺功能衰竭患者提供呼吸支持。氧合膜材料作为其核心部件,起着完成氧合血液和排除二氧化碳的重要作用,需要具有良好的血液相容性、优异的气体渗透和抗血浆渗漏性能。经氧合膜的多次迭代,聚(4-甲基-1-戊烯)中空纤维膜[Poly(4-methyl-1-pentene)Hollow Fiber Membrane,PMP HFM]以其优异的性能成为目前应用于氧合器中的主流膜材料。本文回顾了PMP HFM的发展历程,综述了在制备方法、改性技术和重要性能指标方面的国内研究进展,旨在了解目前国内的发展情况和差距,为未来的研究方向提供更多思路。Extracorporeal Membrane Oxygenation(ECMO)is an extracorporeal membrane oxygenation technology commonly used to provide respiratory support to patients with cardiopulmonary failure.As its core component,oxygenated membrane material plays an important role in oxygenating blood and removing carbon dioxide,which requires good blood compatibility,excellent gas penetration and anti-plasma leakage performance.After several iterations of the oxygenated Membrane,Poly(4-methyl-1-pentene)Hollow Fiber Membrane(PMP HFM)has become the mainstream membrane material used in oxygenators for its excellent properties.In this paper,the development history of PMP HFM is reviewed,and the domestic research progress in preparation methods,modification techniques and important performance indexes is reviewed.In order to understand the current domestic development situation and gaps,and provide more ideas for future research direction.

关 键 词：氧合器 聚(4-甲基-1-戊烯)中空纤维膜 血液相容性 气体渗透性 抗血浆渗漏 

分 类 号：TB324[一般工业技术—材料科学与工程]