从肿瘤免疫到器官移植免疫  

From tumor immunity to organ transplantation immunity

作　　者：周古翔 李一萱 郑瑾[1] Zhou Guxiang;Li Yixuan;Zheng Jin(Department of Kidney Transplantation,the First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China)

机构地区：[1]西安交通大学第一附属医院肾移植科,西安710061

出　　处：《器官移植》2025年第2期229-236,共8页Organ Transplantation

基　　金：陕西省重点研发计划项目(2024SF2-GJHX-21);国家自然科学基金(82170768)。

摘　　要：主要组织相容性复合体在免疫应答过程中扮演着重要角色,与肿瘤的发生发展和器官移植密切相关。细胞免疫在肿瘤免疫和器官移植免疫中占据重要地位,体液免疫在器官移植免疫中的作用同样不可忽视。器官移植需要诱导和维持免疫耐受,而肿瘤发展过程中会产生免疫逃逸现象。深入探讨和比较肿瘤免疫逃逸与器官移植免疫耐受的机制,对于制定合理的免疫耐受诱导策略、提高器官移植患者的生存质量及延长存活时间具有重要意义。The major histocompatibility complex plays a crucial role in the immune response process,which is closely related to the occurrence and development of tumors and organ transplantation.Cellular immunity occupies an important position in tumor immunity and organ transplantation immunity,while humoral immunity also plays a significant role in organ transplantation immunity.Organ transplantation requires the induction and maintenance of immune tolerance,while tumors develop immune escape phenomena during their progression.In-depth exploration and comparison of the mechanisms of tumor immune escape and organ transplantation immune tolerance are of great significance for formulating reasonable immune tolerance induction strategies,improving the quality of life and prolonging the survival time of organ transplant patients.

关 键 词：主要组织相容性复合体 肿瘤免疫 器官移植免疫 免疫逃逸 免疫耐受 排斥反应 抗原提呈细胞 树突状细胞 

分 类 号：R617[医药卫生—外科学] R730.3[医药卫生—临床医学]