基于大脑类淋巴系统清除机制探讨针刺治疗阿尔茨海默病的研究进展  

Research progress on acupuncture treatment for Alzheimer′s disease based on the mechanism of brain-like lymphatic clearance mechanism

作　　者：袁紫嫣 姚春玲 石江伟[1,2] Yuan Ziyan;Yao Chunling;Shi Jiangwei(Department of Acupuncture,First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300381,China;National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Tianjin 300381,China)

机构地区：[1]天津中医药大学第一附属医院针灸部,300381 [2]国家中医针灸临床医学研究中心,天津300381

出　　处：《中华针灸电子杂志》2025年第1期28-33,共6页Chinese Journal of Acupuncture and Moxibustion(Electronic Edition)

基　　金：国家自然科学基金(82374560);天津市中医药重点领域科研项目(2023011)。

摘　　要：阿尔茨海默病(AD)的病因及发病机制复杂,目前尚不明确,现代医学研究认为AD的发病可能与衰老、遗传、自身免疫、环境等因素导致的脑内微环境改变及脑内代谢废物清除异常有关。近年来的研究发现类淋巴系统解释了中枢神经系统的免疫途径,也成为改善脑内微环境及认知障碍的新靶点。综述类淋巴系统清除机制及其可能的影响因素,结合中医经络穴位探讨针刺对类淋巴系统及脑内代谢的作用机制,为今后调控类淋巴系统治疗AD提供新的思路与方法。The etiology and pathogenesis of Alzheimer′s disease are complex and still unclear,and modern medical research suggests that the onset of Alzheimer′s disease may be related to change in the cerebral microenvironment and abnormal clearance of metametabolic waste caused by aging,gheredity,autoimmunity,and environmental factors.Recent studies have found that the lymphoid system explains the immune pathways in the central nervous system and has become a new target for improving the brain microenvironment and cognitive disorders.This article reviews the mechanism of lymphoid system clearance and its possible influencing factors,and discusses the mechanism of acupuncture on lymphoid system and brain metabolism in combination with the meridian points of traditional Chinese medicine,so as to provide new ideas and methods for future modulation of lymphoid system in the treatment of Alzheimer′s disease.

关 键 词：神经胶细胞类淋巴系统 阿尔茨海默病 水通道蛋白质4 针刺疗法 

分 类 号：R24[医药卫生—中医临床基础]