酢浆草组方联合透针治疗湿热瘀滞型慢性非细菌性前列腺炎的临床研究  

Study on the treatment of chronic nonbacterial prostatitis caused by dampness-heat stasis with Oxalis Formula combined with transacupuncture

作　　者：娄强 战明威 赖雨琪 詹绪新 肖友平 商学军[1,2] LOU Qiang;ZHAN Ming-wei;LAI Yu-qi;ZHAN Xu-xin;XIAO You-ping;SHANG Xue-jun(Jinling Clinical Medical College,Nanjing University of Chinese Medicine,Nanjing,Jiangsu 210002,China;Department of Urology,Jinling Hospital Affiliated to Medical School of Nanjing University/General Hospital of Eastern Theater Command,Nanjing,Jiangsu 210002,China;Reproductive Medicine Center,Xi'an People's Hospital/Xi'an Fourth Hospital,Xi'an,Shaanxi 710004,China;Department of Urology,The Second Affiliated Hospital of Guizhou University of Chinese Medicine,Guiyang,Guizhou550001,China)

机构地区：[1]南京中医药大学金陵临床医学院,江苏南京210002 [2]南京大学医学院附属金陵医院/东部战区总医院泌尿外科,江苏南京210002 [3]西安市人民医院/西安市第四医院生殖医学中心,陕西西安710004 [4]贵州中医药大学第二附属医院泌尿外科,贵州贵阳550001

出　　处：《中华男科学杂志》2025年第2期165-171,共7页National Journal of Andrology

基　　金：贵州省科学技术厅基础研究计划项目[黔科合作基础(2018)1012]。

摘　　要：目的:观察酢浆草组方联合透针治疗湿热瘀滞型慢性非细菌性前列腺炎(CNP)临床疗效。方法:纳入2023年4月至2024年7月贵州中医药大学第二附属医院泌尿外科及男科收治70例湿热瘀滞型CNP患者并随机分为对照组和治疗组,每组各35例。对照组给予前列倍喜胶囊治疗,治疗组给予酢浆草组方内服联合透针治疗。疗程均为8周。观察2组患者治疗前后美国国立卫生研究院前列腺症状评分(NIH-CPSI)、中医症候评分、尿动力学参数(最大尿流率、平均尿流率)、免疫细胞亚群含量及炎症因子水平变化情况。结果:最终共纳入患者65例,其中治疗组33例,对照组32例。2组患者治疗8周后,NIH-CPSI总评分、疼痛评分、排尿评分、生活质量评分、中医症状评分、炎性细胞因子水平均较治疗前下降,最大尿流率、平均尿流率、免疫细胞CD4^(+)/CD8^(+)比值较治疗前显著升高(P<0.05)。与对照组相比,治疗组在降低NIH-CPSI总评分、疼痛评分、排尿评分、生活质量评分、中医症状评分、炎性细胞因子水平,以及提高CD4^(+)/CD8^(+)比值、最大尿流率及平均尿流率等方面均优于对照组(P<0.05)。结论:酢浆草组方联合透针治疗湿热瘀滞型CNP具有较好疗效,能够在治疗湿热瘀滞型CNP方面提供新的思路,值得临床进一步探讨。Objective:The aim of this study is to evaluate the clinical efficacy of Oxalicao Formula combined with transacupuncture in the treatment of chronic nonbacterial prostatitis(CNP)characterized by dampness-heat stasis.Methods:A total of 70 patients diagnosed with CNP and characterized by dampness-heat stasis were randomly divided into control group and treatment group,with 35 cases in each group.The patients in control group received Qianlie Beixi capsules.While the patients in treatment group were administered with oxalis decoction in conjunction with acupuncture therapy which lasted for 8 weeks.Pre-and post-treatment evaluations for NIH-Chronic Prostatitis Symptom Index(NIH-CPSI),Traditional Chinese Medicine(TCM)symptom scores,urodynamic parameters,immune cell subsets and inflammatory factors were performed.Results:Ultimately,65 patients completed the study with 33 in the treatment group and 32 in the control group.After 8 weeks of intervention,the patients in both of groups demonstrated significant improvements(P<0.05).Specifically,remarkable reductions in the NIH-CPSI total score including pain score,urination score,quality of life impact score,TCM symptom score and inflammatory cytokine levels were observed.Additionally,there were upward trends in maximum and average urinary flow rates as well as the CD4^(+)/CD8^(+)ratio of immune cells(P<0.05).Compared to the control group,the treatment group exhibited superior outcomes in reducing the NIH-CPSI total score,pain score,urination score,quality of life impact score,TCM symptom score,and inflammatory cytokine levels,and increasing in CD4^(+)/CD8^(+)ratios,maximum and average urine flow rates(P<0.05).Conclusion:The combination of Oxalicao Formula and transacupuncture for treating CNP characterized by dampness-heat stasis demonstrates significant therapeutic benefits,which has considerable clinical application value.

关 键 词：酢浆草组方 透针 慢性非细菌性前列腺炎 湿热瘀滞证 临床试验 

分 类 号：R697.33[医药卫生—泌尿科学] R245[医药卫生—外科学]