高龄对男性精子DNA甲基化及后续对胚胎和子代发育的影响  

Impacts of advanced male age on sperm DNA methylation and subsequent development of embryos and offspring

作　　者：刘雯 房格[1,2,3,4,5,6,7,8] 李晓(综述) 卢少明(审校) LIU Wen;FANG Ge;LI Xiao;LU Shao-ming(Shandong University Research Institute of Women,Children and Reproductive Health/Reproduction Hospital Affiliated to Shandong University,2.National Key Laboratory of Shandong University for Reproductive Medicine and Offspring Health,3.National Research Center of Shandong University for Assisted Reproductive Technology and Eugenic Engineering,4.Shandong University Key Laboratory of the Education Ministry for Reproductive Endocrinology,5.Shandong Province Technology Innovation Center for Reproductive Health,6.Shandong Province Clinical Medical Research Center for Reproductive Health,7.Key Laboratory of Shandong Province for Reproductive Research and Birth Defect Prevention(Under Construction),8.Innovation Unit of the Chinese Academy of Medical Sciences for Gametogenesis and ART-Offspring Health(2021RU001),Jinan,Shandong 250012,China)

机构地区：[1]山东大学妇儿与生殖健康研究院/山东大学附属生殖医院 [2]山东大学生殖医学与子代健康全国重点实验室 [3]山东大学国家辅助生殖与优生工程技术研究中心 [4]山东大学生殖内分泌教育部重点实验室 [5]山东省生殖健康技术创新中心 [6]山东省生殖健康临床医学研究中心 [7]山东省生殖生育研究与出生缺陷防控重点实验室(筹) [8]中国医学科学院配子发生与辅助生殖子代健康研究创新单元(2021RU001),山东济南250012

出　　处：《中华男科学杂志》2025年第2期172-176,共5页National Journal of Andrology

基　　金：山东省医药卫生科技发展计划(202205030189);济南市卫生健康委员会科技计划(2022-2-193)。

摘　　要：男性因素导致不育症的比例与女性因素大致相同,高龄男性精子DNA甲基化对精液参数有直接影响,而且显著降低生育率并增加配偶流产率。尽管许多不利生殖健康结果与男性生育年龄较高有关,但目前对于父亲年龄对子代健康影响的研究较少,且高龄在精子DNA甲基化变异中的作用及后续影响子代健康中的作用机制尚不清楚,这类人群的生育年龄对妊娠结局的影响也应引起重视。因此,本文就男性高龄对精子DNA甲基化及后续对生育结局和子代的影响及其作用机制进行综述,阐明男性高龄对精子DNA甲基化及不利生育结局的影响及机制,可以为临床提供更多有用信息,以期帮助临床解决问题。Male factors contribute to infertility at roughly the same rate as female factors,and sperm DNA methylation in advanced-aged males directly affects semen parameters and significantly reduces fertility and increases the miscarriage rate of spouses.Many adverse outcomes of reproductive health are associated with advanced reproductive age of men,and few studies are reported on the influence of paternal age on the health of the offspring.The role of advanced age in human sperm DNA methylation variation and mechanism of its subsequent influence on the offspring health remain unclear.Attention should be paid to the influence of reproductive age on pregnancy outcomes in this population.This reviews focuses on the impacts of advanced male age on sperm DNA methylation and consequently on reproductive outcomes and the offspring,with elucidation of its underlying mechanisms,aiming to provide some more useful evidence for solving related clinical problems.

关 键 词：DNA甲基化 高龄 男性不育 生育结局 

分 类 号：R321.1[医药卫生—人体解剖和组织胚胎学]