Reductive Synthesis of Alcohols from Carboxylic Acids and Esters Catalyzed by a Copper N-heterocyclic Carbene Complex  

作　　者：Hui Zhou Nana Wei Zhiqiang Ren Haojie Ma Yuqi Zhang Bo Han 

机构地区：[1]Laboratory of New Energy&New Function Materials,Shaanxi Key Laboratory of Chemical Reaction Engineering,College of Chemistry and Chemical Engineering,Yan’an University,Yan’an,Shaanxi,716000 China

出　　处：《Chinese Journal of Chemistry》2025年第1期73-78,共6页中国化学(英文版)

基　　金：financial support from the National Natural Science Foundation of China(22061041);Key Project of Science&Technology of Shaanxi Province(2023-YBGY-430);Project of Science&Technology Bureau of Yulin City(CXY-2022-185);The Youth Innovation Team Project of Shaanxi Provincial Education Department(No.23JP193);National Science Foundation of Shaanxi Province(S2023-JC-QN-0079).

摘　　要：The present work prepared a copper N-heterocyclic carbene complex that could be used in catalyzing the homogeneous hydrogenation of carboxylic acid with ammonia borane(hydrogen source)to synthesize primary alcohols.Various aromatic and aliphatic carboxylic acids with diverse functional groups were transformed to respective alcohols in moderate to high yields.The process can be easily scaled up(TON up to 14545)and exhibits a high compatibility with different sensitive functional groups,including fluorine,chlorine,bromine,iodine,hydroxyl,cyano and nitro groups.IMesCuCl/NH3·BH3 combination can selectively reduce aromatic and aliphatic esters.Mechanistic studies indicate that Cu-H species produced in situ are the active intermediates.

关 键 词：HOMOGENEOUS Reduction COPPER Carboxylic acids ESTERS 

分 类 号：O62[理学—有机化学]