Integrative network analysis identifies pivotal host genes and pathways for SARS-CoV-2 infection  

作　　者：Gao Chen Li Li Ruiqi Wang Bin Liu Zhiwen Cao Ning Zhao Yong Tan Xiaojuan He Jing Zhao Cheng Lu 

机构地区：[1]School of Life Science,Hubei University,Wuhan,Hubei 430062,China [2]Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China

出　　处：《Genes & Diseases》2025年第1期33-36,共4页基因与疾病(英文)

基　　金：funded by the Innovation Team and Talents Cultivation Program Administration Traditional Chinese Medicine(No.ZYYCXTD-D-202005);Youth Qihuang Scholar of National Administration Traditional Chinese Medicine(2020),and Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences(No.CI2021B003).

摘　　要：The coronavirus disease 2019(COVID-19)is still a global threat today.SARS-CoV-2 is the etiologic agent of COVID-19,the culprit behind the current pandemic.Its life cycle is dependent on hijacking host-cell biological processes to facilitate entry,replication,assembly,and budding.The recognition that a suite of mammalian host proteins is required for SARS-CoV-2 infection and replication presents additional targeting strategies that may be less prone to deflections by the quickly mutating viral genome.In this study,we conducted an integrative network analysis to identify pivotal host genes and pathways for SARS-CoV-2 infection.

关 键 词：agent network analysis 

分 类 号：TP3[自动化与计算机技术—计算机科学与技术]