Establishment of a mouse model of respiratory mycoplasma challenged intranasally combined intraperitoneally eliciting chronic inflammation and lung consolidation  

作　　者：Xing Xie Yuan Gan Maoda Pang Lei Zhang Fei Hao Yanna Wei Yi Chen Rong Chen Zhenzhen Zhang Qingyun Xie Daesub Song Guoqing Shao Maojun Liu Qiyan Xiong Zhixin Feng 

机构地区：[1]Key Laboratory for Veterinary Bio-Product Engineering,Ministry of Agriculture and Rural Affairs,Institute of Veterinary Medicine,Jiangsu Academy of Agricultural Sciences,Nanjing,Jiangsu 210014,China [2]Jiangsu Key Laboratory for Food Quality and Safety-State Key Laboratory Cultivation Base,Ministry of Science and Technology,Nanjing,Jiangsu 210014,China [3]GuoTai (Taizhou) Center of Technology Innovation for Veterinary Biologicals,Taizhou,Jiangsu 225300,China [4]Key Laboratory of Control Technology and Standard for Agro-product Safety and Quality,Key Laboratory of Food Quality and Safety of Jiangsu Province-State Key Laboratory Breeding Base,Institute of Food Safety and Nutrition,Jiangsu Academy of Agricultural Sciences,Nanjing,Jiangsu 210014,China [5]College of Veterinary Medicine,Xinjiang Agricultural University,Urumqi,Xinjiang 830052,China [6]College of Veterinary Medicine,Seoul National University,Seoul 08826,South Korea

出　　处：《Genes & Diseases》2025年第1期97-101,共5页基因与疾病(英文)

基　　金：supported by the National Natural Science Foundation of China(No.32273011,32202812);Jiangsu Agricultural Science and Technology Innovation Fund(No.CX(21)3124);Food Quality and Safety-State Key Laboratory Cultivation Base,Ministry of Science and Technology,China(No.2022-SBGJZZ-6);Jiangsu Association for Science and Technology Youth Science and Technology Talents Support Project(China)(No.JSTJ-2023-093).

摘　　要：Mycoplasma hyopneumoniae(Mhp)and Mycoplasma ovipneumoniae(Mo),similar to Mycoplasma pneumoniae(Mp),initiate a chronic respiratory infection with concomitant pulmonary disease,causing substantial harm worldwide.1 A mouse model with genetic consistency helped to elucidate the unknown pathogenic mechanism of respiratory mycoplasmas in large animals and humans.While the intraperitoneal route would facilitate dissemination of infectious agents to the adventitia,combined challenge or immunization would promote replication of microorganisms or vaccine immune effects;for example,intraperitoneal combined intranasal route increased gamma interferonspecific CD8 T cells by more than 60 times after influenza infection.

关 键 词：NASAL PERITONEAL RESPIRATORY 

分 类 号：R375[医药卫生—病原生物学] R-33[医药卫生—基础医学]