PDK1 neddylation by Smurf1 drives Akt activation  

作　　者：Rajesh Kumar Manne Rajni Kant Hui-Kuan Lin 

机构地区：[1]Department of Pathology,School of Medicine,Duke University,Durham,NC,USA

出　　处：《Cell Research》2025年第2期95-96,共2页细胞研究(英文版)

摘　　要：The PI3K/Akt pathway,one of the most frequently dysregulated signaling pathways in various cancers,plays a key role in tumorigenesis and resistance to chemotherapy.Recent discovery highlights an important regulatory step where Smurf1-mediated PDK1 neddylation through poly-Nedd8 chains is an early event for oncogenic Akt activation in KRAS-mutant colorectal cancer.

关 键 词：PI3K/AKT CHEMOTHERAPY ACTIVATION 

分 类 号：R73[医药卫生—肿瘤]