血清脂联素水平与早发血管衰老的相关性  

Correlation analysis between serum adiponectin level and early vascular aging

作　　者：胡锐 王燕[1] 任金岩 王心凤 王诒焓 陈伟芬[1] 丛金鹏 Hu Rui;Wang Yan;Ren Jinyan;Wang Xinfeng;Wang Yihan;Chen Weifen;Cong Jinpeng(Health Management Center,the Affiliated Hospital of Qingdao University,Qingdao 266000,China;Department of Respiratory and Critical Care Medicine,the Affiliated Hospital of Qingdao University,Qingdao 266000,China)

机构地区：[1]青岛大学附属医院健康管理中心,青岛266000 [2]青岛大学附属医院呼吸与危重症医学科,青岛266000

出　　处：《中国医师进修杂志》2025年第3期243-249,共7页Chinese Journal of Postgraduates of Medicine

摘　　要：目的探讨血清脂联素水平与早发血管衰老(EVA)的相关性。方法采用横断面研究方法,选取青岛大学附属医院2023年6—12月行健康体检者672例,根据肱踝脉搏波传导速度(baPWV)分为EVA组(237例)和对照组(435例);依据脂联素三分位数法将体检者分为低脂联素亚组(2.4~6.6 mg/L,225例)、中脂联素亚组(6.7~9.1 mg/L,227例)和高脂联素亚组(9.2~19.8 mg/L,220例)。记录体检者的基本信息、既往史和血清学指标。采用单因素及多因素二元Logistic回归分析影响体检者发生EVA的危险因素,采用多元Logistic回归分析脂联素对EVA的影响。结果EVA组男性比例、年龄、体质量指数(BMI)、收缩压、舒张压、三酰甘油(TG)、空腹血糖(FBG)、尿酸、糖化血红蛋白(HbA_(1)c)、同型半胱氨酸、baPWV和饮酒史比例明显大于对照组[64.98%(154/237)比53.33%(232/435)、53(47,57)岁比46(39,52)岁、(26.34±3.37)kg/m 2比(25.16±3.91)kg/m 2、(132.27±15.48)mmHg(1 mmHg=0.133 kPa)比(117.30±13.04)mmHg、(81.79±11.04)mmHg比(71.93±10.10)mmHg、1.45(1.03,2.03)mmol/L比1.08(0.76,1.65)mmol/L、5.52(5.03,6.21)mmol/L比5.14(4.77,5.56)mmol/L、(380.04±96.43)μmol/L比(362.18±94.94)μmol/L、5.80(5.50,5.90)%比5.70(5.40,5.82)%、10.70(9.01,12.90)μmol/L比9.96(8.30,12.20)μmol/L、1586(1511,1719)cm/s比1299(1215,1367)cm/s和19.41%(46/237)比13.56%(59/435)],脂联素明显低于对照组[7.00(5.70,8.75)mg/L比8.40(6.40,10.60)mg/L],差异有统计学意义(P<0.01或<0.05)。两组总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、肌酐和吸烟史比例比较差异无统计学意义(P>0.05)。低脂联素亚组和中脂联素亚组男性比例、BMI、收缩压、舒张压、TG、FBG、尿酸、肌酐、HbA_(1)c、同型半胱氨酸、EVA发生率、baPWV、吸烟史比例和饮酒史比例明显大于高脂联素亚组,且除HbA_(1)c外低脂联素亚组各指标明显大于中脂联素亚组,差异有统计学意义(P<0.05);低脂联素亚组�Objective To study the relationship between serum adiponectin level and early vascular aging(EVA).Methods The cross-sectional study method was used.Six hundred and seventy-two subjects who completed health checkup from June to December 2023 in the Affiliated Hospital of Qingdao University were selected.The subjects were divided into the EVA group(237 cases)and the control group(435 cases)based on brachial-ankle pulse wave velocity(baPWV).According to the adiponectin tertiles method,the subjects were divided into low adiponectin subgroup(2.4 to 6.6 mg/L,225 cases),medium adiponectin subgroup(6.7 to 9.1 mg/L,227 cases)and high adiponectin subgroup(9.2 to 19.8 mg/L,220 cases).The basic demographic information,past history and serological indexes were recorded.Univariate and multivariate binary Logistic regression analyses were used to analyze the risk factors for EVA,and multivariate Logistic regression was used to analyze the effect of adiponectin on EVA.Results The male proportion,age,body mass index(BMI),systolic blood pressure,diastolic blood pressure,triglycerides(TG),fasting blood glucose(FBG),uric acid,glycated hemoglobin(HbA_(1)c),homocysteine,baPWV and alcohol history proportion in EVA group were significantly higher than those in control group:64.98%(154/237)vs.53.33%(232/435),53(47,57)years old vs.46(39,52)years old,(26.34±3.37)kg/m 2 vs.(25.16±3.91)kg/m 2,(132.27±15.48)mmHg(1 mmHg=0.133 kPa)vs.(117.30±13.04)mmHg,(81.79±11.04)mmHg vs.(71.93±10.10)mmHg,1.45(1.03,2.03)mmol/L vs.1.08(0.76,1.65)mmol/L,5.52(5.03,6.21)mmol/L vs.5.14(4.77,5.56)mmol/L,(380.04±96.43)μmol/L vs.(362.18±94.94)μmol/L,5.80(5.50,5.90)%vs.5.70(5.40,5.82)%,10.70(9.01,12.90)μmol/L vs.9.96(8.30,12.20)μmol/L,1586(1511,1719)cm/s vs.1299(1215,1367)cm/s and 19.41%(46/237)vs.13.56%(59/435),the adiponectin was significantly lower than that in control group:7.00(5.70,8.75)mg/L vs.8.40(6.40,10.60)mg/L,and there were statistical differences(P<0.01 or<0.05).There were no statistical differences in total cholesterol(TC),high-density lipopr

关 键 词：脂联素 血管 衰老 动脉硬化 

分 类 号：R543[医药卫生—心血管疾病]