甲状腺功能减退妊娠期女性血清甲状腺激素水平与低出生体质量儿的关系  

Relationship Between Serum Thyroid Hormone Levels and Low Birth Weight Infants in Women With Hypothyroidism Pregnancy

作　　者：孙丹华 嵇萍 冯奇 SUN Danhua;JI Ping;FENG Qi(Department of Obstetrical,the Huanghe Sanmenxia Hospital,Sanmenxia Henan 472000,China)

机构地区：[1]黄河三门峡医院产科,河南三门峡472000

出　　处：《中国卫生标准管理》2025年第2期25-28,共4页China Health Standard Management

摘　　要：目的探讨甲状腺功能减退妊娠期女性血清甲状腺激素水平与低出生体质量儿的关系。方法选取2020年10月—2023年1月于黄河三门峡医院诊治的孕早、中、晚期甲状腺功能减退妊娠期女性各60例。另外选取产检正常的孕早、中、晚期妊娠期女性各60例。比较妊娠期女性体内甲状腺激素水平和新生儿体质量的变化情况及分析二者关系。结果2组游离四碘甲状腺原氨酸(free tetraiodothyronin,FT4)水平比较,差异无统计学意义(P>0.05)。与对照组比较,观察组妊娠期女性游离三碘甲状腺原氨酸(free triiodothyronine,FT3)水平、新生儿出生体质量、阿普加评分降低,促甲状腺激素(thyroid stimulating hormone,TSH)水平升高[(4.51±1.09)pmoL/L vs.(5.52±1.20)pmoL/L,(3.19±0.83)pmoL/L vs.(4.83±1.01)pmoL/L(,3.97±1.21)pmoL/L vs.(5.07±1.33)pmoL/L,(3.11±1.27)m IU/mL vs.(2.13±0.82)mIU/mL,(6.02±2.51)mIU/mL vs.(4.25±1.77)mIU/mL,(5.96±2.01)mIU/mL vs.(5.02±1.81)mIU/mL],差异均有统计学意义(P<0.05)。甲状腺功能减退妊娠期女性的FT3与新生儿体质量分别呈正相关,TSH水平与新生儿体质量呈负相关(P<0.05)。结论甲状腺功能减退妊娠期女性的血清FT3和TSH水平与低出生体质量儿的发生密切相关,及时监测和调整母体甲状腺激素水平对于预防低出生体质量儿具有重要意义。Objective To investigate the relationship between serum thyroid hormone levels and low birth weight infants in hypothyroidism pregnancy.Methods A total of 60 pregnant women with hypothyroidism in early,middle and late pregnancy from the Huanghe Sanmenxia Hospital from October 2020 to January 2023 were selected.In addition,60 pregnant women in early,middle and late pregnancy were selected.The changes of thyroid hormone levels in pregnant women and newborn body weight were compared and the relationship between them were analyzed.Results There was no significant difference in free tetraiodothyronine(FT4)levels betw een the tw o groups(P>0.05).Compared with the control group,the levels of fe male free triiodothyronine(FT3),newborn birth weight and Apgar score during pregnancy in the observation group were decreased,and the levels of thyrotropin(TSH)were increased in the observation group[(4.51±1.09)pmoL/L vs.(5.52±1.20)pmoL/L].(3.19±0.83)pmoL/L vs.(4.83±1.01)pmoL/L,(3.97±1.21)pmoL/L vs.(5.07±1.33)pmoL/L,(3.11±1.27)mIU/mL vs.(2.13±0.82)mIU/mL,(6.02±2.51)mIU/mL vs.(4.25±1.77)mIU/mL,(5.96±2.01)mIU/mL vs.(5.02±1.81)mIU/mL],the differences were statistically significant(P<0.05).There was a positive correlation between FT3 and neonatal body mass,and a negative correlation between TSH and neonatal body mass(P<0.05).Conclusion Serum FT3 and TSH levels of women in hypothyroidism pregnancy are closely related to the occurrence of low birth weight infants.Timely monitoring and adjusting maternal thyroid hormone levels are of great significance for the prevention of low birth weight infants.

关 键 词：甲状腺功能减退 甲状腺激素 不同孕期 妊娠期女性 低出生体质量儿 相关性 

分 类 号：R581[医药卫生—内分泌]